氯敌鼠钠盐对布氏田鼠的急性毒力研究  

A Study on Acute Toxicity of Chlorophacine-sodium in Brandti's Voles

作　　者：高志祥[1] 王晓军[2] 吴新平[2] 叶继明[2] 施大钊[1] 

机构地区：[1]中国农业大学,北京100094 [2]农业部农药检定所

出　　处：《中国媒介生物学及控制杂志》2006年第3期177-179,共3页Chinese Journal of Vector Biology and Control

基　　金：国家"十五"科技攻关项目(2004BAS09B18)

摘　　要：目的测定氯敌鼠钠盐对布氏田鼠的急性毒力。方法依据孙氏改良寇氏综合计算法,以测试致死中量(LD50)的方式,配制8个浓度梯度的氯敌鼠钠盐药液供给试鼠;试验采用经口一次灌胃法。结果根据各浓度结果测得其LD50值为5.913 mg/kg,s-x为0.082 mg/kg,95%平均可信限为(5.913±2.172)mg/kg;该药对雌雄鼠的毒力差异无统计学意义(P>0.05)。结论按毒力分级标准,该药达到剧毒水平,在实际鼠防工作中可作为慢性毒药的补充。Objective To determine acute toxicity of chlorophacine-sodium in Brandti＇s voles （Lasiopodornys brandtii）. Methods Brandti＇s voles were treated with chlorophacine-sodium via gastric tube at concentrations of eight gradients based on its median lethal dose （ LD50 ） by modified＇ s Kǎirber＇s method. Results LD20 of chlorophacine-sodium in Brandti＇s voles was 5.913 mg/kg with a standard error of 0. 082 mg/kg and 95 % confidence limit of（5.913 ± 2. 172）mg/kg, without significant difference between male and female voles by χ^2 test （P〉0.05 ）. Conclusion Acute toxicity of chlorophacine-sodium in Brandti＇s voles reached the highest level according to classification standard for toxic chemicals in mice and could be used as an alternative rodenticide with chronic-toxicity in rat control.

关 键 词：氯敌鼠钠盐 布氏田鼠 急性毒力 致死中量 

分 类 号：R979.8[医药卫生—药品] S443[医药卫生—药学]