急性冠脉综合征患者血浆CD_(40)L水平及与血管黏附分子之间关系  

The Study of Plasma CD_(40)L Level and it′s Correlation to the Soluble Vascular Adhesion Molecules in Acute Coronary Syndrome

作　　者：虞华鹏[1] 高成志[1] 刘建民[1] 赵震[1] 赵成军[1] 

机构地区：[1]济南市第四人民医院济南市心血管病研究所,济南250031

出　　处：《医学综述》2006年第11期703-704,共2页Medical Recapitulate

摘　　要：目的观察冠心病不同类型患者中CD40L水平的变化及其与血管性黏附分子之间的关系,进一步探讨急性冠脉综合征临床识别和预测的炎症指标。方法采用酶联免疫吸附法测定血清可溶性CD40L(sCD40L)、可溶性细胞间黏附分子-1(sICAM-1)和可溶性血管细胞黏附分子-1(sVCAM-1)浓度。结果急性冠脉综合征患者sCD40L水平(3.48±2.17)μg/L显著高于对照(1.26±0.97)μg/L,P<0.01和稳定性冠心病患者(1.48±1.06)μg/L,P<0.05。sCD40L水平与可溶性细胞间黏附分子-1呈显著正相关(r=0.376,P<0.01)。结论急性冠脉综合征患者外周血sCD40L水平升高,可能与急性冠脉综合征的发生有关,是动脉粥样硬化斑块不稳定的标志。CD40L可能通过上调黏附分子表达而促发急性冠脉综合征。Objective To investigate the difference of sCD40 L Level in different subtype of coronary heart disease and it＇s relationship with vascular adhesion molecules and to explore the potential predicting factor for the acute coronary syndrome（ ACS）. Methods Enzyme -linked Immunosorbent Assay was used to measure the plasma sCD40L, soluble intercellular adhesion molecule-1, and soluble vascular cell adhesion molecule-1. Remits sCD40L level was significantly higher in patients with ACS[ （3.48 ±2.17） μg/L] than those in of the control group[ （ 1,26 ± 0.97）μg/L, P 〈 0.01）and in patients with stable coronary heart disease[ （1.48 ± 1.06）μg/L, P 〈 0.05 ）. sCD40 L level was positively correlated with soluble intercellular adhesion molecule-1 （ r = 0. 376, P 〈 0.01 ）. Conclusion The elevated sCD40 L level in ACS suggested its possible relation with the pathogenesis of ACS, which may serve as a potential marker of unstable atherosclerotic plaque. The positive correlation between CD40 L and adhesion molecules may indicate the possible mechanism by which CD40L facilitates the ACS via up-regnlating the adhesion molecules expression.

关 键 词：冠状动脉疾病 CD40L 黏附分子 

分 类 号：R541.4[医药卫生—心血管疾病]