耐亚胺培南铜绿假单胞菌耐药性分析  

ANTIBIOTIC-RESISTANT SPECTRA AND OF IMIPENEM-RESISTANT PSEUDOMONAS AERUGINOSA

作　　者：刘峰 钱君明 刘峰 李琳琳 

机构地区：[1]九江市第五人民医院,江西九江332000 [2]广东省广州市花都区新华镇医院,广东广州510800

出　　处：《九江学院学报（自然科学版）》2006年第2期51-53,65,共4页Journal of Jiujiang University：Natural Science Edition

摘　　要：目的：探讨住院病人临床标本中分离的耐亚胺培南铜绿假单胞菌(IRPA)的耐药情况,以指导临床有效使用抗生素。方法：按常规方法对铜绿假单胞菌进行分离培养,VITEK—Ⅱ全自动细菌鉴定仪进行药敏实验采用纸片扩散(K-B)法,按2005年NCCLS标准对结果进行判读,使用whonet5.3软件对数据进行统计处理。结果：60株IR-PA对14种常用抗生素的耐药率分别为：头孢他啶100.0％,头孢哌酮／舒巴坦98.0％,头孢吡肟72.0％,哌拉西林70％,哌拉西林／他巴坐坦71.7％,替卡西林／克拉维酸85.0％,美洛培南75％,氨曲南78.3％,环丙沙星51.7％,左氧沙星氟78.3％,阿米卡星35.0％,庆大霉素45.0％,复方新诺明98.3％。除环丙沙星、庆大霉素、复方新诺明外,IRPA组的耐药率明显高于亚胺培南敏感铜绿假单胞菌(ISPA)组,差异有统计学意义(P＜0.05)。结论：IRPA对大多数常用抗生素呈现出更强的耐药性。OBJECTIVE： Studying the resistance of [RPA （imipenem resistant Pseudomonas aeruginosa） isolated from the Second Affiliated Hospital SUN YAT - SEN University to direct the use of antibiotic agents. METHOD： Strains were isolated and cultured in routine procedures, and identified by VITEK - Ⅱ. Antibiotic Susceptibility Test （AST） were proceeded by disc - diffusion （ K - B ） method, the results were determined according to guidelines made by NCCLS （ National Committee Clinical Laboratory Standards）. And whonet.5. 3 software was applied to dealing with the data. RESULTS： Resistant rate of IRPA tO 16 common used antibiotic agents are showed as follows ： Ceftazidime （ 100. 0% ）, Cefoperazone/sulbactam （ 98. 0% ）, Cefepime （ 72. 0% ）, Piperacillin （70%）, PiperacilIin. tazobactam （71. 7% ）, Ticarcillin - clavulanic acid （85%）, Meropenem （75%）, Aztreonam （78. 3%）, Ciprofloxacin （5 1. 7%）, Levofloxacin （78. 3%）, Amikacin （3 5%）, Gentamitin （45. 0% ）, Trimethoprim - sulfonamides （ 98. 3% ）. Except, Gentamicin, Ciprofloxacin and Trimethoprim - sulfonamides, resistant rate of IRPA group is obviously higher than the ISPA group. And the difference iS significant （ P 〈 0. 05 ）. CONCLUSIONS： IRPA demonstrate higher resistance to common used antibiotic agents.

关 键 词：亚胺培南耐药 铜绿假单胞菌 耐药性 医院感染 

分 类 号：R96[医药卫生—药理学]