去氢胆酰苯并三唑的合成及反应活性  

Synthesis and reactive behavior of dehydrocholyl benzotriazole

作　　者：黄涛[1] 黄开勋[2] 

机构地区：[1]中南民族大学化学与材料学院分析化学国家民委重点实验室,湖北武汉430074 [2]华中科技大学化学系,湖北武汉430074

出　　处：《武汉化工学院学报》2006年第3期7-9,共3页Journal of Wuhan Institute of Chemical Technology

基　　金：湖北省教育厅科研基金(2003A007)

摘　　要：采用二环己基碳二亚胺缩合法由去氢胆酸和苯并三唑合成了去氢胆酰苯并三唑,产率60%,并利用FTIR和1HNMR对产物进行了表征.通过考察去氢胆酰苯并三唑对胰岛素的化学修饰作用,进一步证实该酰化苯并三唑的合成是成功的,并且对胰岛素的侧链氨基具较高的修饰反应活性.Dehydrocholyl benzotriazole was synthesized from dehydrocholic acid and benzotriazole with the method of dicyclohexylcarbodiimide coupling reaction and the yield was about 60% ,and its structure was characterized by FT - IR and ^1H NMR, Dehydrocholyl benzotriazole showed a high reaction activity in the chemical modification of insulin and it confirmed that the synthesis of dehydrocholyl benzotriazole was successful.

关 键 词：去氢胆酸 苯并三唑 去氢胆酰苯并三唑 

分 类 号：Q578[生物学—生物化学] R977.15[医药卫生—药品]