去甲肾上腺素并多巴酚丁胺治疗脓毒性休克伴顽固性低血压28例临床分析  

Effect of arginine vasopressin in the treatment of the septic shock with lasting hypotension

作　　者：韩国强[1] 潘国权[1] 

机构地区：[1]温州医学院附属育英儿童医院,浙江温州325000

出　　处：《中国急救医学》2006年第6期426-428,共3页Chinese Journal of Critical Care Medicine

摘　　要：目的评价应用去甲肾上腺素并多巴酚丁胺治疗脓毒性休克伴顽固性低血压的疗效。方法应用去甲肾上腺素并多巴酚丁胺治疗28例脓毒性休克伴顽固性低血压,对照组18例应用大剂量多巴胺并多巴酚丁胺,评价治疗前及治疗12 h后两组的血压、心率、尿量、CRT、乳酸水平及EF值。治疗72 h后统计两组MODS发生率及死亡率。结果治疗12 h后,治疗组血压上升,心率下降,尿量增加,CRT缩短,乳酸下降,EF值增加,与治疗前及对照组比较,差异有统计学意义(P<0.05)。治疗72 h后两组MODS发生率及死亡率比较差异有统计学意义(P<0.05)。结论去甲肾上腺素并多巴酚丁胺用于脓毒性休克能有效地升高血压,改善循环与灌注,提高脓毒性休克伴顽固性低血压救治成功率。Objective To evaluate the effect of small dose arginine vasopressin in the treatment of septic shock with lasting hypotension. Mothods Small dose of arginine vasopressin and dobutamin were used in the treatments of the 26 children cases （ treatment group） who are suffered with septic shock. On the other hand, high （lose of dopamine and dobutamin were used in the 16 children cases（ control group）, In the treatment group ：before treatment and 8 - 12 hours after treatment, blood pressure, heart rate, urine volume, capillary refilled time（CRT） were compared between treatment group and controls one. Results After 12 hours＇ treatment, blood pressure, heart rate, urine volume, CRT were significantly different between treatment group and control one （ P 〈 0.05 ）. Conclusion The use of small dose arginine vasopressin can impove blood pressure, the microcirculation and infuse of organs in ,serve septic shock; thus, it is a useful tool in the treatment of septic shock,

关 键 词：去甲肾上腺素 多巴酚丁胺 脓毒性休克 血压 灌注 

分 类 号：R720.597[医药卫生—急诊医学]