维生素C溶液有氧降解动力学  

Kinetic Studies on the Oxidative Degradation of Vitamin C Solution

作　　者：史焱[1] 詹先成[1] 吕太平[1] 马烈[1] 曹呈勇[1] 舒晓明[1] 李成容[1] 李琳丽[1] 何宁[1] 

机构地区：[1]靶向药物教育部重点实验室四川大学华西药学院,成都610041

出　　处：《化学学报》2006年第11期1189-1194,共6页Acta Chimica Sinica

基　　金：国家自然科学基金(No.30472104)资助项目.

摘　　要：建立了一种恒温高压氧药物稳定性加速试验方法,用这种方法可在较短的时间内求得药物氧化反应的动力学参数.以10%维生素C溶液为例,维生素C在有氧和无氧条件下均可降解,总的降解速率常数kt由两部分构成:kt=kan+kae,kan为无氧降解速率常数,可表达为kan=Aan?exp(-Ea,an/RT);kae为有氧降解速率常数,可表达为kae=Aae?exp(-Ea,ae/RT)?pO2.An isothermal experiment with high pressure oxygen was established. The stability of 10% vitamin C solution as a model drug was studied and the kinetics parameters were obtained in a short time with the newly established experimental method. Because vitamin C degrades in both anaerobic and aerobic conditions, the total rate constant kt can be expressed as： kt =kan＋kae, where kan and kac are the anaerobic and aerobic degradation rate constants, respectively. The kan can be expressed as kan=Aan·exp（-Ea,an/RT） according to Arrhenius equation, and the kae was found to be kae=Aac·exp（-Ea,ac/RT）·Po2 in our experiments.

关 键 词：恒温高压氧加速试验 药物稳定性 降解动力学 氧 维生素C 

分 类 号：TQ460.1[化学工程—制药化工]