^(117)Sn^m(^(113)Sn)(Ⅳ)-四(4-磺酸苯基)卟啉的制备  

Preparation of()^(117)Sn^m(^(113)Sn)(Ⅳ)-TPPS_4

作　　者：蒲满飞[1] 罗顺忠[1] 杨玉青[1] 刘国平[1] 李有根[1] 王晓坤[1] 

机构地区：[1]中国工程物理研究院核物理与化学研究所,四川绵阳621900

出　　处：《核化学与放射化学》2006年第2期111-116,共6页Journal of Nuclear and Radiochemistry

摘　　要：为了研制对辐射增敏的、肿瘤治疗用的117Snm放射性药物,研究了117Snm(113Sn)(Ⅳ)与四(4-磺酸苯基)卟啉(TPPS4)的反应条件和该配合物的体外稳定性及其化学计量组成。研究结果表明,用天然丰度的金属锡粒作靶料,在中子注量率为4×1013cm-2.s-1的条件下,照射90 h,可以获得比活度为0.13 GBq/g的117Snm和6.16 MBq/g的113Sn;在pH为2~4、沸水浴中反应30 min时,117Snm(113Sn)(Ⅳ)-TPPS4标记率大于95%。该放射性配合物有良好的稳定性和抗生理盐水稀释性能,室温下放置48 h或用生理盐水稀释5~15倍,其放化纯度基本不变;该配合物中Sn(117Snm(113Sn))与TPPS4的配位比为1∶1。Development of ^117 Sn^m radiopharmaceuticals with radiosensitization ability to the treatment of tumors is valuable since such agents may increase therapeutic effects. In this paper, ^117 Sn^m （^113 Sn） was prepared by irradiation of spectrally pure natural metallic tin grain with reactor thermal neutrons （neutron fluence rate 4× 10^13 cm^-2 · s^-1） for a period up to 90 h, yielding ^117 Sn^m and ^113 Sn with specific activity of 0.13 GBq/g and 6.16 MBq/g respectively, and meso-tetrakis（4-sulfonatophenyl） porphyrin （TPPS4） was labeled with ^117 Sn^m （^113 Sn） in aqueous solution. The optimized preparation conditions are as follows：pH=2-4, reaction temperature about 100 ℃, reaction time 30 min. Under the recommended experimental conditions, the yield of ^117 Sn^m-TPPS4 is higher than 95 %. No significant decomposition of the ^117 Sn^m-TPPS4 complex solution is observed either during the standing period of 48 h after its preparation, or after the dilution of it with physiological saline to 5 -15 times at room temperature. A 1 ： 1 stoichiometry of the ^117 Sn^m TPPS4 complex is obtained by the job＇s method.

关 键 词：^117Sn^m ^117Sn^m(^113Sn)(Ⅳ)-TPPS4 辐射敏化 肿瘤 

分 类 号：O614.713[理学—无机化学]