肾上腺髓质素缓慢注入对盐敏感大鼠的肾脏保护作用  

Renoprotective effect of chronic adrenomedullin infusion in salt-sensitive rat

作　　者：王新[1] 杜如跃[1] 锦见俊雄 

机构地区：[1]首都医科大学附属北京安贞医院抢救中心,北京100029 [2]日本独协医科大学病院循环内科

出　　处：《临床心血管病杂志》2006年第6期343-346,共4页Journal of Clinical Cardiology

摘　　要：目的:探讨缓慢注入肾上腺髓质素(AM)对高血压引起的肾衰竭大鼠的肾脏保护作用及其机制。方法:Dahl盐敏感(DS)大鼠18只和盐抵抗(DR组)大鼠9只从6周龄开始喂以高盐饮食形成肾衰竭模型。11周龄时将DS大鼠分为2组:DS-AM组(9只)注入重组人AM,DS组(9只)注入0.9%氯化钠溶液,均7周。结果:7周后,DS组及DS-AM组大鼠表现为肾功能减退、形态异常、激素水平升高。但与DS组比较,DS-AM组大鼠的肾功能以及组织学表现可显著改善,并抑制血浆肾素浓度及醛固酮水平的增加(P<0.01),而平均动脉压没有改变,DR组、DS组、DS-AM组大鼠的肾小球损伤分数分别为13.13、95.65、47.82,两两比较均差异有统计学意义(P<0.01或P<0.05)。结论:增加内源性AM对慢性高血压性肾衰竭起代偿作用,长期注入AM在该高血压模型中可部分通过抑制循环及肾素-血管紧张素系统而发挥肾脏保护作用。Objective：To explore the renoprotective effects of chronic adrenomedullin infusion has renoprotec rive effects in hypertensive renal failure and the mechanism by which chronic adrenomedullin infusion exerts its effects. Method： Dahl salt sensitive rats and Dahl salt resistant rats were fed or a high salt diet starting at 6 weeks of age. Recombinant human adrenomedullin or vehicle was infused for 7 weeks in 11-week old Dahl salt sensitive rats. Dahl salt.resistant rats were chosen as a control. Result： After 7 weeks, untreated Dahl salt sensitive rats were characterized by decreased kidney function, abnormal morphological findings, increased hormone levels. Chronic adrenomedullin treatment significantly improved renal function and histological findings without changing mean arterial pressure compared with untreated Dahl salt-sensitive rats, Chronic adrenomedullin treatment also significantly inhibited the increase of plasma rennin concentration and aldosterone level. Conclusion：These results suggest that increased endogenous adrenomedullin plays a compensatory role in chronic hypertensive renal failure and that long term adrenomedullin infusion has renoprotective effects in this type of hypertension model, partly via inhibition of the circulating and renal renin-angiotensin system.

关 键 词：高血压 肾功能衰竭 肾上腺髓质素 

分 类 号：R543.1[医药卫生—心血管疾病]