前胡对大鼠缺氧性肺动脉高压逆转效应的实验观察  

Experimental Studies on Inhibitory Effects of Radix Peucedani on Hypoxic Pulmonary Hypertension in Rats

作　　者：席思川[1] 阮英茆[1] 张连庄[1] 司文学[1] 李洪涛 

机构地区：[1]中国医学科学院阜外心血管病医院病理科

出　　处：《中国中西医结合杂志》1996年第4期218-220,共3页Chinese Journal of Integrated Traditional and Western Medicine

基　　金：国家"八五"攻关课题资助

摘　　要：本实验用生理指标测定、心脏解剖称重、形态学观察和形态计量学方法，动态观察中药前胡对低氧大鼠腺泡内肺动脉（ＩＡＰＡ）构形重组及肺动脉高压（ＰＨＴ）形成的逆转恢复作用。结果表明：前胡不仅能拮抗缺氧性ＩＡＰＡ收缩，降低肺动脉压力，抑制肺动脉壁细胞增殖与肥大，还能在一定程度上逆转肺动脉高压的结构和功能。提示前胡也是治疗低氧性ＩＡＰＡ构型重组和肺动脉高压的有效药物之一。Light microscopic and morphometric methods along with the measurement of right ventricular systolic pressure(RVSP) and right ventricle hypertrophy index(RBHI) were performed by the authors in studying the inhibitory effects of Radix Peucedani(RP) on structural remodeling of intraacinar pulmonary arteries(IAPA) and pulmonary hypertension(PHT) in hypoxic rats.The results showed that,RP could not only antagonize IAPA contraction caused by hypoxia and lower the resistance of pulmonary circulation,inhibit the cell proliferation and hypertrophy of adventitial cells of pulmonary artery,but also reverse the change in structure and function of pulmonary artery.It suggests that RA plays a key role in inhibiting hypoxic structural remodeling of IAPA and pulmonary hypertension.

关 键 词：前胡 缺氧 肺动脉高压 药理 大鼠 

分 类 号：R282.710.5[医药卫生—中药学] R259.432[医药卫生—中医学]