针刺治疗对恶性肿瘤患者细胞免疫调节的影响  

Effect of Acupuncture on Immunomodulation in Patients with Malignant Tumors

作　　者：吴滨[1] 周荣兴[1] 周鸣生[1] 龚其美[1] 赵北蓉 陈名金[1] 李婉宜[1] 张永玲[1] 屈一云 陈平[1] 

机构地区：[1]华西医科大学附属第一医院针灸科,华西医科大学基础医学院微生物教研室,华西医科大学卫生统计教研室

出　　处：《中国中西医结合杂志》1996年第3期139-141,共3页Chinese Journal of Integrated Traditional and Western Medicine

基　　金：四川省中医药管理局资助

摘　　要：本研究采用双盲法随机分组，对４０例实体恶性肿瘤患者外周血Ｔ淋巴细胞亚群，可溶性白细胞介素－２受体（ＳＩＬ－２）和β－内啡肽（μ－ＥＰ）含量进行了同步检测和对比观察。结果表明：针刺具有提高恶性肿瘤患者细胞免疫功能的作用，针刺治疗可增加恶性肿瘤患者Ｔ淋巴细胞亚群ＣＤ３＋、ＣＤ４＋、提高ＣＤ４＋／ＣＤ８＋的比值（ｐ＜０．０１）；降低患者的ＳＩＬ２Ｒ含量（Ｐ＜０．０１）；提高其β－ＥＰ水平（Ｐ＜０．０１）。并对３项指标进行了相关分析，发现β－ＥＰ与Ｔ细胞亚群之间呈正相关，与ＳＩＬ－２Ｒ之间呈负相关，Ｔ细胞亚群与ＳＩＬ－２Ｒ之间亦存在负相关。并以此为依据。对针刺──免疫调节网络进行了探讨，以阐明针刺调节免疫功能的可能途径和机理。In order to investigate the role of acupuncture in the regulation of cellular immune function, the changes of T lymphocyte subsets(CD3+, CD4+, CD8+), soluble interleukin-2 receptor(SIL-2 R) and β-endorphine(β-EP) in the peripheral blood of patients with malignant tumors before and after acupuncture were observed with double blind method. Forty patients were divided randomly into two groups, 20 for each. One group treated with acupuncture and the other one for control. Results showed that acupuncture has the effect of enhancing the cellular immunity of patient with malignant tumor. Acupuncture treatment could increase the percentage of T lymphocyte subsets CD3+, CD4+ and the CD4+/CD8+ ratio(p<0.01)and the level of β-EP, as well as decrease the level of SIL-2 R(P<0.01). The correlation analysis of the three criteria showed there was a positive correlation between β-EP and T lymphocyte subsets and a negative correlation between β-EP and SIL-2 R, there was also a negative correlation between T lymphocyte subsets and SIL-2 R. Based on these results, a discussion on the acupuncture immunomodulation network was conducted in this article in order to explore the possible mechanism of acupuncture on immunomodulation.

关 键 词：针刺疗法 恶性肿瘤 T淋巴细胞亚群 Β-内啡肽 

分 类 号：R245.31[医药卫生—针灸推拿学] R246.5[医药卫生—中医临床基础]