灵芪安神口服液对免疫抑制小鼠红细胞免疫功能及抗氧化作用的调节  

Regulatory Effect of Lingqi Anshen Liquor on Erythrocyte Immune Function and Antioxdation in Immunosuppressed Mice

作　　者：汤斌[1] 何德[1] 刘彩琼[1] 

机构地区：[1]广东医学院微生物学与免疫学教研室,广东医学院生化教研室

出　　处：《中国中西医结合杂志》1996年第3期167-169,共3页Chinese Journal of Integrated Traditional and Western Medicine

基　　金：广东医学院青年科学基金

摘　　要：为研究灵芪安神口服液对免疫抑制小鼠红细胞免疫功能及抗氧化作用的调节，我们给环磷酰胺抑制小鼠模型灌服灵芪安神口服液共７天。实验结果表明，灵芪安神口服液能明显拮抗环磷酰胺对小鼠红细胞免疫功能及抗氧化作用的抑制，使环磷酰胺抑制小鼠血清超氧化物歧化酶（ＳＯＤ）活力、红细胞免疫粘附促进因子及红细胞Ｃ３ｂ受体花环率（ＲＢＣ－Ｃ３ｂＲＲ）提高；而使环磷酰胺抑制小鼠血清中丙二醛（ＭＤＡ）含量、红细胞免疫粘附抑制因子及红细胞免疫复合物花环率（ＲＢＣ－ＩＣＲ）降低。提示：灵芪安神口服液具有调节免疫功能低下小鼠红细胞免疫功能及其抗氧自由基损伤的作用。The regulatory effect of Lingqi Anshen Liquor(LQASL) on erythrocyte immune function and antioxidation in cyclophosphamide induced immunosuppressed model mice was observed. After given LQASL for 7 days, the results showed that it could antagonize the inhibitory action of cyclophosphamide significantly, demonstrated by raising the level of superoxide dismutase activity, erythrocyte immune adhesive euhance factor and erythrocyte C3b receptor rosette forming rate, lowering the serum malondialdehyde, erythrocyte adhesive inhibitory factor and erythrocyte immunocomplex rosette forming rate. It suggested that LQASL can regulate the erythrocyte immune function and antagonize the injury of oxygen free radical in ininiunosuppressed mice.

关 键 词：灵芪安神口服液 红细胞 超氧化物歧化酶 药理学 

分 类 号：R285.5[医药卫生—中药学]