Mg^（2＋）对离体灌流环孢素A的大鼠肾脏血流动力学影响  

ProtectiveeffectofMg2+onrenalhemodynamicofisolatedperfusedratkidneywithcyclosporineA

作　　者：杨黄[1] 张景红[1] 丁群凤 

机构地区：[1]解放军第八五医院肾内科

出　　处：《中华肾脏病杂志》1996年第3期160-162,共3页Chinese Journal of Nephrology

摘　　要：了解血镁浓度与环孢素Ａ（ＣｓＡ）肾损害之间的关系。方法采用大鼠离体肾灌流模型，观察了Ｍｇ２＋对ＣｓＡ的急性肾脏效应的影响。结果正镁（１．２ｍｍｏｌ／Ｌ）时ＣｓＡ５０ｍｇ／Ｌ灌流引起显著的肾血管痉挛和肾灌注不良，以及Ｃａ２＋聚积和Ｍｇ２＋耗竭；在低镁（０．１２ｍｍｏｌ／Ｌ）时，ＣｓＡ的作用明显增强；而高镁（４．８ｍｍｏｌ／Ｌ）时，ＣｓＡ的作用受到了有效的抑制。结论适当提高Ｍｇ２＋浓度能改善离体肾血流动力学和克服ＣｓＡ对肾脏的影响。鉴于使用ＣｓＡ的患者常有低镁血症，因此适当补镁对防治ＣｓＡ肾毒性具有一定意义。bjectiveToinvestigatetherelationshipbetweenserumMg2+concentrationandrenaldamagebycy-closporineA(CsA).MethodsTheefectofMg2+onrenalfunctionchangesinducedbyCsAwasobservediniso-latedperfusedkidneyofSpragueDawleyrats.ResultsTheperfusionofCsA(50mg/L)couldinducetherenalvascularconstriction,thedecreaseofrenalplasmaflow(RPF)andGFR(P<0.05)withanaccumulationofCa2+andalossofMg2+(P<0.05)inthekidney.TherenalactionofCsAwasmuchmoreprominentwhentheconcen-trationofMg2+inperfusionfluidwasloweredfrom1.2mmol/Lto0.12mmol/L(RPFandGFRwerebroughtdownto24.1%±6.3%and25.6%±4.3%respectively,andinthekidneyMg2+decreasedby20%whereasCa2+increasedby4%)whilesignificantlybluntedwiththeperfusionofMg2+at4.8mmol/L.ConclusionTheprotec-tiveefectofMg2+ontherenalfunctionchangesinducedbyCsAmightberelatedwiththeamountofinhibitionofCa2+influxintotherenalcels.ItissuggestedthatsuficientMg2+supplementationinpracticebeobviouslybenefi-cialtoprotectthekidneyagainstCsAassociatednephrotoxicity.

关 键 词：镁 环孢素A 离体肾 血液动力学 

分 类 号：R965.3[医药卫生—药理学] R979.5[医药卫生—药学]