冠心病合并糖尿病患者血栓前状态分子标志物的变化  

Change and significance of molecular markers of prethrombotic state in coronary artery disease patients with diabetes mellitus

作　　者：李结华[1] 唐海沁[1] 

机构地区：[1]安徽医科大学第一附属医院干部病房心内科,合肥230022

出　　处：《中国临床保健杂志》2006年第3期212-214,共3页Chinese Journal of Clinical Healthcare

基　　金：安徽省卫生厅科学研究基金资助课题(2002A036)

摘　　要：目的观察冠心病(CHD)合并2型糖尿病(T2DM)患者血栓形成前状态(PTS)分子标志物的变化。方法检测冠心病组74例(稳定型心绞痛32例,不稳定型心绞痛19例,UAP合并T2DM23例)和正常对照组20例体内PTS分子标志物,并回归分析其之间的相关性。结果与正常对照组比较,冠心病组尤其是合并T2DM患者体内存在明显的PTS分子标志物变化,VWF、D-D、FIB水平显著升高,AT-Ⅲ活性下降,并与心脏事件发生密切相关。结论PTS分子标志物的检测对冠心病尤其是合并T2DM患者高凝状态的诊断和治疗具有指导意义。Objective To investigate the changes of molecular markers of prethrombotic state（PTS） in coronary heart disease patients with diabetes mellitus （T2DM）. Methods Molecular markers of PTS were measured in 74 patients （32 patients with stable angina pectoris, 19 patients with unstable angina pectoris,23 unstable angina pectoris patients with T2DM） and 20; nomal controls, and the relationships of the items were analyzed. Results As compared with normal controls, there were significant changes of molecular markers of PTS in CHD patients, especially in those with T2DM. the levels of plasma VWF,D-D,FIB were significantly higher, while the activity of AT-HI was significantly lower. Regression analysis showed that there were close relationships between cardiac events and VWF,D- D,FIB,AT-Ⅲ. Conclusion The determination of molecular markers of PTS has important value for the diagnosis and treatment of high coagulation state in CHD patients, especially in those with T2DM.

关 键 词：冠状动脉疾病 糖尿病 2型 血栓形成倾向 生物学标记 

分 类 号：R541.4[医药卫生—心血管疾病] R587.1[医药卫生—内科学]