慢性乙型肝炎血清蛋白电泳与肝组织病理分级分期的关系  

Relationship between serum protein electrophoresis and grading and staging of liver tissue in patients with chronic hepatitis B

作　　者：陈乐无[1] 吴洁伟[1] 明朗[1] 王功遂[1] 姜湘宁[1] 谢秋里[1] 郑翀[1] 

机构地区：[1]顺德市一人民医院内六科,广东顺德528300

出　　处：《现代医药卫生》2006年第13期1925-1926,共2页Journal of Modern Medicine & Health

摘　　要：目的:探讨慢性乙型肝炎患者血清蛋白电泳与肝组织病理分级分期的关系。方法:用法国产sebiaHYDRASYS全自动电泳分析仪及其配套的血清蛋白电泳试剂盒检测236例慢性乙型肝炎患者血清中白蛋白(AIb):α1、α2、β、γ球蛋白;同时行肝组织活检并对肝组织进行炎症活动度分级(G)和纤维化程度分期(S)。结果:随着肝脏的炎症和纤维化程度分别加重,AIb、α2球蛋白逐渐下降,α1、γ球蛋白逐渐升高。AIb、α2、γ球蛋白在G2、G3、G4比较差异有显著性(P<0.05),α1球蛋白在G4与G1、G2,G3与G2比较差异有显著性(P<0.05);AIb、α1、γ球蛋白S1、S2与S3、S4比较差异有显著性(P<0.05);α2球蛋白在S2、S3、S4比较差异有显著性(P<0.05)。G3、G4、S3、S4级患者α2球蛋白降低,G4期患者γ球蛋白增高。结论:AIb、α1、α2、β、γ球蛋白能反映肝损害的严重程度和肝纤维化的程度,其中α2、γ球蛋白最有价值。Objective：To study the relationship between serum protein electrophoresis and grading and staging of liver tissue in patient with chronic hepatitis B. Methods：The serum protein electrophoresis of 236 patients with chronic hepatitis B was determined with sebia HYDRASYS autochemieal analyzer made in France. Liver biopsy was conducted simultaneously to determine the inflammation grade and fibrosis stage of the liver tissues. Results：The hepatic activity index and .hepatic fibrosis increased as albumin and α2-globulin level decreased gradually,αl-globulin and γ-globulin level increased gradually. There was obviously difference of albumin,α2-globulin, γ-globulin level in G2, G3 and G4（P〈0.05）.There was obviously difference of αl-globulin level in G4 and G1, G2,in G3 and G2（P〈 0.05）. There was obviously difference of albumin, α1l-globulin, γ-globulin level in S1 ,S2 and S3, S4（P〈0.05）. There was obviously α1- ference of α2-globulin level in S2 and S3 and S4 （P〈0.05）. Conclusion：The serum protein electrophoresls could reflect the severity degree of grading and staging of liver tissues in patient with chronic hepatitis B . The α2-globulin and γ-globulin were useful index.

关 键 词：乙型肝炎 慢性 血清蛋白电泳 肝组织病理 

分 类 号：R512.62[医药卫生—内科学]