乙肝患者胃肠道肿瘤的高风险  

The relation of hepatitis B virus and the high incidence of multiple digestive system tumors

作　　者：顾建兴[1] 许国新[1] 樊黎[1] 王丰[1] 

机构地区：[1]苏州大学附属第四医院检验科,江苏无锡214062

出　　处：《现代医药卫生》2006年第14期2095-2096,共2页Journal of Modern Medicine & Health

摘　　要：目的:检测患者血清乙肝病毒DNA-PCR、糖蛋白抗原CA199、糖蛋白抗原CA125、癌胚抗原(CEA)、甲胎蛋白(AFP),结合检测结果,统计和研究乙肝患者胃肠道肿瘤的发病概率。方法∶乙肝病毒DNA检测用PCR法定量;CA199,CA125,CEA,AFP采用电化学发光法,选择1664例住院患者且乙肝DNA病毒拷贝数大于500拷贝/ml,其中295例经病理组织学和临床确诊为胃肠道肿瘤患者,再结合CA199,CA125,CEA,AFP高低来分别统计,分析各种胃肠道肿瘤的发生比例和趋向性。结果:乙肝病毒DNA-PCR拷贝数高于6000拷贝/ml好几年的患者或带菌年数较长的中年患者胃肠道肿瘤发病率很高,与正常人群差异有显著性(P<0.01)。结论∶乙肝病毒DNA-PCR升高的患者及病程长的人群中胃肠道肿瘤趋势增高。Objective：To select the patients suffering from digestive system tumors among the patients with hepatitis B virus then,to count and research the patients of combined hepatic B virus DNA with CA199,CA125,CEA,AFP test on digestive system tumors.Methotis： PCR for DNA and eleetrochemiluminescence for CA199,CA125,CEA,AFP test,1 664 inpatients with〉500 copy/ml hepatitis B virus copy level were selected, among them,295 patients had been diagnosed suffering from digestive system tumors by histopathology and clinic.Combined with CA199,CA125,CEA,AFP,the ratio and tendency of tumors were analyzed respectively.Results：There was a significant difference in the high incidence of digestive system tumors between normal people and patients with hepatitis B virus DNA more than 6 000 copy/ml last several years or the long term virus carriers （P〈0.01）. Conclusion：There is a tendency that patients with a high level of hepatitis B type virus of long term virus carriers is subject to suffering from digestive system tumors.

关 键 词：胃肠道肿瘤 乙肝DNA-PCR 糖蛋白抗原CA199 糖蛋白抗原CA125 癌胚抗原 甲胎蛋白 

分 类 号：R446[医药卫生—诊断学]