罗库溴铵和维库溴铵应用于快速气管插管的时效比较  

Comparison of rocuronium and vecuronium for rapid endotracheal intubation

作　　者：周伟 李朝阳 李震 罗小敏 辜雄军 

机构地区：[1]深圳市南山人民医院麻醉科,广东深圳518052

出　　处：《现代医药卫生》2006年第14期2116-2118,共3页Journal of Modern Medicine & Health

摘　　要：目的:比较罗库溴铵与维库溴铵在全麻诱导后气管插管时的起效时间、肌松程度、插管条件及其组胺释放情况。方法:将合格受试的患者80例,随机分为两组,每组40例,均于静脉注射异丙酚2mg/kg和芬太尼0.3!g/kg,同时予纯氧面罩吸入120秒钟后,在前臂静脉10秒内分别快速注射肌松药。治疗组肌松药给罗库溴铵0.9mg/kg,对照组给维库溴铵0.15mg/kg,行气管插管。用4个成串(TOF)刺激(频率2Hz,串间间隔15秒)通过尺神经,用拇内收肌收缩束判断肌松效应,以T1颤搐值(%)作为判断肌松效应的指标,待T1稳定100%后开始给药观察。并且评估插管条件、组胺释放情况以及循环功能变化。结果:观察组和对照组的起效时间分别为(1.61±0.67)分钟、(3.62±0.95)分钟,两组比较差异有显著性(P<0.01)。而在临床作用时间,以及恢复指数上,两组比较差异无显著性(P>0.05);观察组插管条件优秀31例,良好7例,满意率为97.5%,总有效率为100%;对照组优秀29例,良好8例,满意率为92.5%,总有效率为97.5%。两组插管条件比较差异无显著性(P>0.05);两组病人均未出现支气管痉挛和皮疹情况。结论:罗库溴铵起效时间优于维库溴铵,而在临床作用时间、恢复指数、插管条件与维库溴铵相似,两组均无明显心血管不良反应。罗库溴铵是快速诱导气管插管时的良好肌松药。Objective：To compare the neuromuscular block effect and side effect of rocuronium and vecuronium for rapid endotracheal intubation.Methods：Eighty adult patients were equally divided into two groups.Their neuromuscular block effect and side effect were observed,and the onset time,clinical duration and recovey were recorded.Results：The onset time of rocuronium was （1.61±0.67）min,which was significantly shorter than （3.62±0.95）min of vccuronium.Bronchospasm and skin eruption didn＇t occur and the hemodynamic changes were unobvious in both groups.Conclusion：Rocuronium is quicker in onset without cardiovascular side effects and suitable choice of relaxants for rapid endotracheal intubation.

关 键 词：罗库溴铵 维库溴铵 全麻诱导 气管插管 

分 类 号：R614[医药卫生—麻醉学]