改良的简易精神状态检查量表在狼疮认知筛查中的应用  

The usefulness of the modified mini-mental status examination for cognitive dysfunction screening in lupus

作　　者：陆晓晔[1] 郭起浩[2] 范维[1] 王元[1] 洪震[2] 周燕[2] 

机构地区：[1]上海交通大学医学院附属仁济医院风湿免疫科,200001 [2]复旦大学附属华山医院神经内科

出　　处：《中华风湿病学杂志》2006年第6期355-358,共4页Chinese Journal of Rheumatology

基　　金：上海市重点学科建设基金(T0203)

摘　　要：目的建立系统性红斑狼疮(SLE)患者认知功能检查的床边筛查量表。方法应用改良的简易精神状态检查量表(modified mini mental status examination,MMMSE,华山医院神经内科修订版)对SLE患者进行认知功能检查,并与传统的简易精神状态检查量表(mini mental status examinmion,MMSE)检查作比较。结果①MMSE检查结果显示,神经精神性狼疮(NPSLE)组得分低于正常对照组(P＜0．01),但与SLE对照组比较差异无统计学意义(P＞0．05)；完成时间长于SLE对照组和正常对照组(P＜0．01)；SLE对照组较正常对照组在得分和完成时间上差异无统计学意义(P＞0．05)：②MMMSE检查结果显示：NPSLE组得分低于SLE对照组和正常对照组(P＜0．01),完成时间长于SLE对照组和正常对照组(P＜0．01)；而SLE对照组得分较正常对照组低,完成时间长于正常对照组,差异有统计学意义(P＜0．01)。结论MMSE一直是国内外最普及、最常用的痴呆筛查量表,但其反映认知功能损伤不够敏感,而3MSE在增加的几个项目测试中能较敏感地发现认知损伤,而且易操作、费时少(10min以内),可以用于SLE床边认知筛查。Objective To establish the bedside screening scale for cognition examination in systemic lupus erythematosus patients. Methods The modified mini-mental status examination （MMMSE） （revised by the Neurology Department of Hua Shan Hospital） was applied to examine the recognition function of SLE patients. The results were compared with those of the traditional mini-mental status examination （MMSE）. Results MMSE examination results showed that NPSLE score was lower than that of normal control group （P〈0.01）, no significant difference was found between NPSLE patients and SLE control group （P〉0.05）, and the completion time was longer than SLE control group and normal control group （P〈0.01）; but no significant difference was found between SLE control group and normal control group. The result of MMMSE examination showed that the score of NPSLE group was lower than that of SLE control group and normal control group （P〈0.01）, and the completion time was longer than SLE control group and normal control group （P〈0.01）; but the score of SLE control group was lower than the normal control group, and its completion time was longer than normal control group, the difference was statistically significant （P〈0.01）. Conclusion MMSE is the most widely used dementia scale, but it is not sensitive in demonstrating the impairment of recognition function. The several items we added to the MMMSE can detect recognition impairment more sensitively, and can be very easily applied, costs less time （within 10 minutes）. Therefore, it can be used for SLE bedside screening.

关 键 词：红斑狼疮 系统性 狼疮血管炎 中枢神经系统 认知 筛查量表 

分 类 号：R593.241[医药卫生—内科学]