活性炭对扑热息痛的吸附行为和体外释放性能  

The adsorption of paracetamol by activated carbons and its subsequent release

作　　者：梁栋[1] 吕春祥[1] 李云兰[2] 李永红[1] 袁淑霞[1] 

机构地区：[1]中国科学院炭材料重点实验室中国科学院山西煤炭化学研究所 [2]山西医科大学药学院,山西太原030001

出　　处：《新型炭材料》2006年第2期144-150,共7页New Carbon Materials

摘　　要：主要研究了药用颗粒活性炭对扑热息痛的吸附行为和体外释放性能。采用N2吸附表征了三种活性炭的孔结构,借助Beohm滴定法和质量滴定法测定了活性炭的表面含氧官能团和零电荷点pHPZC;考察了比表面积、孔隙结构与吸附性能和体外释放性能的关系,及活性炭表面化学性质对吸附性能的影响。结果表明:活性炭的孔结构和表面化学性质对吸附性能和体外释放性能具有决定性的影响。比表面积高、孔隙发达、孔径分布集中在2nm^11nm之间的中孔型活性炭,对扑热息痛的吸附力很强,平衡吸附量达到了358m g/g,累计释放率为7%;具有广谱孔径分布的活性炭,平衡吸附量为281m g/g,可以缓释12h以上,累计释放率达到27%。活性炭表面的酸性含氧官能团对吸附扑热息痛具有一定的促进作用。三种活性炭的释药过程均符合H iguchi方程释药模式。The adsorption by and release of paracetamol from activated carbon （AC） with different pore structures and surface chemical properties were studied. The pore structure, specific surface area, surface chemical properties and pH at the point of zero charge of the AC were tested with N2 adsorption, Boehm titration and mass titration respectively. An AC with high specific surface area, and abundant mesopores ranging between 2 and 11 nm, exhibited excellent adsorption performance to paracetamol. Its adsorption capacity was 358 mg/g, and its total release rate was 7 % in 12 h. The adsorption capacity of an AC with wider pore size distribution was 281 mg/g and its total release rate reached 27 % in 12 h. The paracetamol adsorption capacity was higher on the AC which had a higher content of surface oxygen groups and exhibited an acidic character.

关 键 词：活性炭 比表面积 表面官能团 缓释 扑热息痛 

分 类 号：TQ460.1[化学工程—制药化工]