降钙素基因相关肽在运动病大鼠前庭传出性中枢神经系统和前庭核的表达变化  

Changes of Calcitonin Gene Related Peptide in Efferent Vestibular System and Vestibular Nuclei in Rats with Motion Sickness

作　　者：王小成[1] 冯立宁[1] 张作明[1] 慧瑞[2] 武胜昔[2] 

机构地区：[1]第四军医大学航空航天医学系临床医学教研室,陕西西安710032 [2]第四军医大学基础部人体解剖学教研室,陕西西安710032

出　　处：《航天医学与医学工程》2006年第3期167-170,共4页Space Medicine & Medical Engineering

摘　　要：目的通过观察运动病大鼠降钙素基因相关肽(CGRP)在前庭传出性中枢神经系统和前庭核的表达变化,探讨中枢CGRP在运动病发病过程中的作用。方法30只SD大鼠随机分为3组,其中不给予旋转运动刺激的为对照组,其它两组实验动物通过电动转椅分别给予3次和1次运动性刺激,刺激后即刻取各组动物脑干切片,用ABC法观察传出性前庭神经系统和前庭核的CGRP免疫组化反应变化。结果运动病大鼠前庭传出性神经系统和前庭核CGRP反应与对照组相比明显增强,且刺激3次组强于刺激1次组。结论CGRP在大鼠运动病的发病过程中发挥了一定的作用。Objective To study the changes of calcitonin gene related peptide（CGRP） in the etterent vestibular system and vestibular nuclei in rats with motion sickness. Method Thirty rats were divided into 2 experimental groups and 1 control group,and rats in the 2 experimental groups were treated with rotatory stimuli for 30 rain 1 time and 3 times respectively. CGRP in rat efferent vestibular sys- tem and vestibular nuclei were observed utilizing ABC immnunohistochemical technique. Result Number of CGRP immunoreactivity neurons in the efferent vestibular system and level of CGRP immunoreactivity in vestibular nuclei increased significantly in rats after rotatory stimuli, and the changes were greater in the goup with 3 times of stimuli than those in the group with 1 time of stimulus. Conclusion CGRP might play a role in the process of motion sickness in rat.

关 键 词：降钙素基因相关肽 运动病 前庭传出系统 前庭核 基因表达 

分 类 号：R852.33[医药卫生—航空、航天与航海医学]