肾动脉狭窄患者肾动脉支架置入术后再狭窄及肾功能和血压的改变  

Evaluation of restenosis,renal function and blood pressure after the renal artery stenting in patients with atherosclerosis renovascular disease

作　　者：王焱[1] 巩燕[1] 叶涛[1] 郑剑涛[1] 王挹青[1] 黄卫斌[1] 陈炳煌[1] 陈水龙[1] 何世华 

机构地区：[1]厦门大学附属中山医院厦门心脏中心,361004 [2]香港玛丽医院肾科

出　　处：《中华肾脏病杂志》2006年第6期332-335,共4页Chinese Journal of Nephrology

摘　　要：目的评估肾动脉支架术后再狭窄的发生及肾功能及血压的改变。方法对135 例单侧或双侧肾动脉明显狭窄(管腔内径减少≥70％)的患者行肾动脉支架置入术(PTRAS),术后行肾动脉造影、血压及血肌酐(Scr)的随访观察。结果 135例患者植入147枚支架均获成功。术后肾动脉造影随访率70％,平均随访时间为(7．2±5．6)月,再狭窄率为7．4％。血压及肾功能随访率为95％,平均随访时间(22±6)月,随访患者的收缩压与舒张压均明显下降,分别为 [(172±23)比(159±20)mm Hg,P<0．05,(93±16)比(85±13)mm Hg,P<0．05]。但术后12个月及24个月Scr和GFR与术前比较无显著性差异。结论肾动脉支架置入术后的再狭窄率较低,PTRAS有助于患者的血压控制。Objective To evaluate the restenosis, renal function and blood pressure after renal artery stenting in patients with atherosclerosis renovascular disease. Methods Percutaneous renal artery stont （PTRAS） was performed in 135 patients with single or bilateral renal artery stenosis （≥70%）.Clinical data of above patients were studied during follow-up period. Results A total of 147 stents were successfully deployed in 145 lesions of 135 consecutive patients. Seventy percent of the patients were followed-up by renal artery angiography for an average of （7.2±5.6） months. The restenosis rate of the renal artery was 7.4%. Ninety-five percent of patients were followed-up for blood pressure and renal function for an average of （22±6）months. The systolic and diastolic pressure were significantly decreased from 172±23/93±16 mm Hg to 159±20/85±13 mm Hg（P 〈 0.05）. The serum creatifine level and glomerular filtration rate （GFR） did not change significantly during 12 months and 24 months follow-up. Conclusions Implantation of renal artery stent benefits the improvement of blood pressure in the patients with atherosclerosis renal vascular disease with a low renal artery restenosis rate.

关 键 词：动脉硬化 肾动脉梗阻 血压 支架 再狭窄 

分 类 号：R692[医药卫生—泌尿科学]