川芎嗪对低气压噪声环境条件下豚鼠听阈改变的影响  

Effects of tetramethyl pyrazine (TMP) on noise induced hearing loss in hypobaric environment

作　　者：冯悦[1] 纵亮[2] 黄华 杨国庆[1] 朱建光[1] 

机构地区：[1]解放军第252医院耳鼻喉科,保定071000 [2]解放军总医院第一附属医院耳鼻喉科 [3]西安长安国际医院耳鼻喉头颈外科

出　　处：《解放军医学杂志》2006年第6期595-596,共2页Medical Journal of Chinese People's Liberation Army

摘　　要：目的探讨川芎嗪对低气压及噪声环境下听阈阈移的影响。方法豚鼠随机分为两大组:造模1天组、造模7天组。每大组再随机分为3小组:阳性对照组、川芎嗪治疗组、川芎嗪防治组。模拟高原5500m高度,并给以110dBSPL白噪声刺激,通过检测听性脑干反应阈移值,观察川芎嗪对低气压及噪声环境下听阈阈移的影响。结果暴露后各组豚鼠都出现不同程度的阈移,以4kHz处阈移最明显;阈移值随着低压噪声环境暴露时间的延长而增加,暴露时间越长阈移值越大。阳性对照组阈移较治疗组及防治组明显。结论川芎嗪对低压及噪声暴露的豚鼠的听阈阈移具有一定防治作用。Objective To evaluate the effect of tetramethyl pyrazine（TMP）on noise induced heating loss （NIPIL） in hypobaric environment. Methods Normal guinea pigs were randomly divided into two groups, in which the animals were exposed to noise for 1 day or 7 days, respectively. Each group was randomly divided into 3 subgroups., control, TMP-treatment and TMP-pretreatrnent groups. All anirnals were exposed to 110dB white noise in hypobaric chamber to repreduce a low pressure environment of 5500m altitude. The mechanism underlying TMP protection was studied by detecting the auditory brainstem response （ABR）. Results ABR threshold shift in different degrees occurred in every group, especially in animals exposed to 4kHz. The threshold shifts increased in extent along with prolongation of exposure time. The longer they were exposed, the more ABR threshold shifts. ABR threshold shifts occurred more severely in control group compared with the two TMP-utilized groups. Conclusion TMP has certain protective effect on NIHL in a hypobaric environment.

关 键 词：川芎嗪 低气压 诱发电位 听觉 脑干 听觉丧失 噪声性 

分 类 号：R764.3[医药卫生—耳鼻咽喉科]