大剂量纳洛酮治疗安眠药合并酒精混合中毒患者疗效观察  

The effect of high-dose Naloxone treatment on intoxation of hypnotic and alcohol

作　　者：俞锐敏[1] 章仕坚[1] 蒋亚斌[1] 黄新智[1] 蒋建华[2] 

机构地区：[1]暨南大学附属第一医院急诊科,广州510630 [2]安徽医科大学第一附属医院,合肥230022

出　　处：《安徽医科大学学报》2006年第3期351-352,共2页Acta Universitatis Medicinalis Anhui

摘　　要：目的观察不同剂量纳洛酮治疗急性安眠药、酒精混合中毒的临床疗效。方法70例混合中毒患者随机分为大剂量组和常规剂量组,对两组催醒时间、症状持续时间、治疗24h前后APACHE-Ⅱ、Glasgow评分进行统计分析。结果大剂量组催醒时间、症状持续时间比常规剂量组短(P<0·05),两组治疗24h后APACHE-Ⅱ、Glasgow评分差异均有显著性(P<0·01),大剂量组APACHE-Ⅱ、Glasgow评分改善幅度较常规剂量组差异有显著性(P<0·05)。结论安眠药、酒精混合中毒时选用大剂量纳络酮治疗比常规剂量效果更显著。Objective To evaluate the effect of different dosage of Naloxone treatment on intoxation of hypnotic and alcohol. Methods Seventy patients suffering from intoxation were randomly divided into two groups： the low-dose group and the high-dose group. The time of anabiosis, the duration of symptom, APACHE- Ⅱ and Glasgow grading system were observed and recorded. Results In high-dose group, the time of anabiosis and the duration of symptom were shorter. There was clearly improvement comparing before and after 24 h treatment in each group when evaluated by both APACHE-Ⅱ and Glasgow grading system（ P 〈0. 01 ）, but the high-dose group was significandy better than the low-dose group （P 〈 0. 05 ）. Conclusion High-dose Naloxone treatment on intoxation of hypnotic and alcohol is more effective than low-dose.

关 键 词：酒精中毒/药物疗法 催眠药和镇静药/中毒 纳洛酮/治疗应用 

分 类 号：R459.7[医药卫生—急诊医学] R595.4[医药卫生—治疗学]