赛百粉针对难治性肾病综合征凝血/纤溶系统的影响  

Effect of the Powdery Injection of Saibai on Coagulative and Fibrinolytic System in Refractory Nephrotic Syndrome

作　　者：刘启华[1] 汪南海 魏连波[1] 龙海波[1] 周伟东[1] 汤珣[1] 肖玮[1] 钟娟[1] 

机构地区：[1]南方医科大学珠江医院中西医结合肾病中心,广州510282 [2]湖北省赤壁市第一人民医院,赤壁437300

出　　处：《中国中西医结合肾病杂志》2006年第6期339-341,共3页Chinese Journal of Integrated Traditional and Western Nephrology

基　　金：南方医科大学珠江医院院长基金资助项目(No.200303)

摘　　要：目的:探讨赛百粉针对难治性肾病综合征(RNS)凝血/纤溶系统的影响。方法:30例RNS随机分为治疗组与对照组,在常规治疗基础上,治疗组加用纤溶酶制剂赛百粉针,对照组加用低分子肝素钙速碧林注射液,比较两组治疗前后24h尿蛋白、组织型纤溶酶原激活物(t-PA)、纤溶酶原激活物抑制物1(PAI-1)活性及血浆纤维蛋白原(Fib),D-二聚体(D-D)、纤溶酶原(PLG)含量、部分凝血活酶时间(APTT)、凝血酶原时间(PT)的变化。结果:治疗1个疗程后,治疗组与对照组尿蛋白均显著下降(P≤0.001),两组间治疗前、后比较均无差异(P>0.05);t-PA、PLG治疗前治疗组与对照组均较健康组明显下降(P<0.005),PAI-1、D-D、Fib明显升高(P≤0.000),PT、APTT显著缩短(P≤0.000),两组间比较均无差异(P>0.05)。t-PA、PLG治疗后治疗组与对照组均较治疗前显著升高(P<0.05),PAI-1、Fib、D-D显著下降(P≤0.005),除t-PA对照组升高更显著(P=0.018),PAI-1两组比较无统计学差异外(P>0.05),D-D、Fib、PLG治疗组变化较对照组更显著(P≤0.005)。治疗后两组PT延长均无统计学意义(P>0.05),APTT对照组显著延长(P=0.021),治疗组无显著延长(P=0.155)。结论:赛百粉针能显著改善RNS凝血/纤溶异常,减少蛋白尿,有助于RNS的缓解。Objective： To investigate the clinical efficacy on coagulative and fibrinolytic system in refractory nephrotic syndrome（RNS） with Powdery Injection of Saibai. Methods： 30 patients of primary RNS were randomly divided into treat ment and control group. The treatment group were treated with Powdery Injection of Saibai,and the control group with Injection of Subilin both on the basis of routine therapies. The 24 h proteinuria and t - PA,PAI - 1 ,Fib,PLG,D - D, VF, APTT were tested before and after the therapies. Results： After one therapy course, the 24 h proteinuria of the two groups decreased significantly（P≤0. 001）. The t- PA,PLG were deereased（P〈0.005）,the PAI- 1,D D,Fib inereasecl（P≤ 0. 000）and the PT, APTT were shortened obviously（ P = 0. 000）in the two groups compared with healthy one before the therapies, with no differences for all the forementioned parameters at the base line （P〉0.05）. After the therapies, the t - PA,PLG in the two groups increased dramatically （P 〈 0.05） and the PAI - 1 ,D- D,Fib decreased （P≤0. 005）. The D- D, Fib,PLG were changed more significantly in treated group than that in the control group＇s（ P = 0. 005）except that the t - PA decreased more obviously in the control group（ P - 0.018） and no differences for the PAI - 1 （ P 〉 0.05）. The PT of both groups had the trend to prolong, but no significanees（P 〉0.05）. Lastly, the APTT prolonged significantly in the control group （P = 0.021 ） while not in the treatment one（P = 0.155）. Conclusion：Powdery Injection of Saibai was superior in ame liorating hypofibrinolysis,hypercoagulability to that of the Injection of Subilin in RNS, and displayed notable effects in attenuating proteinuria.

关 键 词：赛百粉针 难治性肾病综合征 凝血/纤溶 

分 类 号：R692.3[医药卫生—泌尿科学]