乙型肝炎病毒感染对肾小球肾炎致病作用的比较分析  

Comparative Analysis on the Pathogenic Effect of Hepatitis B Virus Infection on Glomerulonephritis

作　　者：于艳[1] 张静[2] 王汉民[1] 陈威[1] 连耀国[1] 刘宏宝[1] 刘彦仿[2] 

机构地区：[1]第四军医大学西京医院肾内科,西安710032 [2]第四军医大学西京医院病理科,西安710032

出　　处：《中国中西医结合肾病杂志》2006年第6期342-344,374,共4页Chinese Journal of Integrated Traditional and Western Nephrology

基　　金：国家自然科学基金资助项目(No.30400213)

摘　　要：目的:探讨乙型肝炎病毒(HBV)感染对肾小球肾炎(GN)的致病作用。方法:应用免疫组织化学方法,检测49例血清HBV阳性和15例HBV阴性患者肾组织内HBV标志物(HBsAg、HBeAg、HBcAg)分布的状况,并对比两组患者的临床表现、化验检查和肾组织病理类型。结果:(1)两组在性别、年龄、24h尿蛋白定量、合并血尿、肝功能受损、肾功能受损和血清免疫学指标方面无明显差异(P>0.05);(2)HBV标志物阳性组肾组织内HBV标志物检出率与阴性组相比无明显差异(P>0.05);(3)两组所致肾小球肾炎的病理类型方面无统计学差异(P>0.05)。结论:HBV可能直接感染肾组织细胞导致肾炎的发生。Objective：To observe the roles of hepatitis B vires （HBV） infection in the pathogenesis of glomerulonephritis. Methods：Forty- nine cases of glomerulonephritis with positive serum HBV markers and fifteen cases of glomerulonephritis with negative serum HBV markers were collected. HBV markers（HBsAg,HBeAg,HBcAg）were detected by immunohistochemical techniques in these renal tissues. In addition, the clinicopathological changes of the positive group （A） and the negative group （B） were compared. Results： （1）There was no significant difference between the two groups in the sex, the age, the 24h urinary protein quota, haematuria, the liver function, the kidney function and the blood serum immunology target aspect（P 〉0.05）;（2）There was no significant difference of HBV- markers between the two groups（P 〉 0.05）;（3） There was also no significant difference in pathology between the two groups （P 〉 0.05）. Conclusion： This results suggests that glomerulonephritis might result from direct infection of HBV in kidney.

关 键 词：乙型肝炎病毒相关性肾炎 膜性肾病 临床表现 肾脏病理 

分 类 号：R692.3[医药卫生—泌尿科学]