PEG作为成孔剂对聚(N-异丙基丙烯酰胺-co-丙烯酸)水凝胶性能的影响  

EFFECT OF PEG AS PORE-FORMING AGENTS ON THE PROPERTIES OF POROUS POLY(N-ISOPROPYLACYLAMIDE-co-ACRYLIC ACID) HYDROGELS

作　　者：张建涛[1] 黄世文[1] 薛亚楠[1] 卓仁禧[1] 

机构地区：[1]武汉大学化学与分子科学学院生物医用高分子材料教育部重点实验室,武汉430072

出　　处：《高分子学报》2006年第3期418-423,共6页Acta Polymerica Sinica

基　　金：国家重点基础研究发展规划项目(项目号G1999064703);国家自然科学基金(基金号20204009)资助项目

摘　　要：以PEG400,1000,6000为成孔剂,合成了一系列聚(N-异丙基丙烯酰胺co丙烯酸)水凝胶,研究了成孔剂分子量和数量对凝胶性能的影响.结果表明,聚乙二醇(PEG)分子充当成孔剂,不参与反应.PEG分子量越大,投料越多,所得凝胶孔的孔径越大,孔数目越多,在室温时可以容纳更多的水分子,因而溶胀率也越大.凝胶的大孔结构有利于水分子的进出,所以响应速率比普通共聚凝胶快.随着PEG分子量增大,孔数目增多,响应速率相应变快.A series of porous poly （ N-isopropylacrylamide-co-acrylic acid） [ P （ NIPA-co-AA ） ] hydrogels were prepared by radical polymerization using PEG400, 1000,6000 as pore-forming agents during the reaction process. SEM macrographs revealed that the pore size of the hydrogels could be modulated by adjusting the molecular weight or the amount of PEG. The swelling ratio of the porous gels at room temperature was higher than that of the conventional P（NIPA-co-AA） hydrogels due to the porous microstructure. When the hydrogels were transferred to an aqueous medium of 60℃, they shrank rapidly to an equilibrium state and exhibited faster response properties. What＇s more, the swelling ratio and responsive rate increased with elevating the molecular weight or the amount of PEG. The prepared macroporous hydrogels have potential applications in controlled release of macromolecular active agents.

关 键 词：温度敏感 聚(N-异丙基丙烯酰胺) 聚丙烯酸 水凝胶 大孔 聚乙二醇 

分 类 号：TQ317[化学工程—高聚物工业]