萘哌地尔衍生物BWYJ对前列腺增生大鼠组织形态学的影响  

Effect of naf topidil's ramif ication BWYJ on histomorphological change of benign prostatic hyperplasia in castrated rats

作　　者：于爽[1] 余丽梅[1] 吴芹[1] 孙安盛[1] 石京山[1] 袁牧[2] 

机构地区：[1]遵义医学院药理学教研室 [2]贵州省中科院天然产物重点实验室,贵州贵阳550002

出　　处：《遵义医学院学报》2006年第1期15-17,共3页Journal of Zunyi Medical University

基　　金：国家自然科学基金资助(NO30060087)

摘　　要：目的观察萘哌地尔衍生物BWYJ对前列腺增生大鼠组织形态学的影响。方法采用SD大鼠去势后皮下注射丙酸睾丸酮法复制前列腺增生模型。H.E.染色观察各组大鼠前列腺组织形态改变;同时结合图像分析系统,检测各组腺体腔直径和腺体横断面积的变化。结果光镜下,与正常组相比,模型组前列腺上皮细胞呈高柱状、数目增多,呈分枝乳头突向管腔,腺腔内无或仅有少许红色分泌物。与模型组相比,BWYJ治疗4wk后,各剂量组(5、10、20mg.kg-1)不同程度地可使增生的上皮乳头减少或消失,间质减少,腺体腔直径、面积减少(P<0.05)。结论BWYJ 5、10、20 mg.kg-1组对丙酸睾丸酮诱发的大鼠前列腺组织结构增生性改变有抑制作用。Objective To observe effect of BWYJ on histomorphological changes of benign prostatic hyterplasia in castrated rats. Methods After castrated, SD rat were injected subcutancously testosterone propionatc to induce BPH. Prostatic tissucs were stained by hemoloxylin and eosin , then morphometric changes of glandular were semi-quantified by image analysis system Results Through light-mieroscope , glands in the model group were lined intensively , lumina of glands was incrcased and local cpithclia were overgrowth and infolded into the tubular lamina . The epithelia were columnar and few cytoplasm （ cosinophilic hyaline seeretion） were accumulated within the glandular lumina. While in the BWYJ- treated groups, hyperplasia epithelia and papillary configuration were decrcased . The epithelium were. cubical or flatty while the nucleci were round amidst of the cell ,stromal complements decreased. And glandular rmaxium diameters and areas declined. Conclusions BWYJ can inhibited histomorphological changes of BPH induced by testosterone propioate in castrated SD rat.

关 键 词：BWYJ 前列腺增生 形态定量学 

分 类 号：R972[医药卫生—药品]