组织超声回波时移温度相关性及其无创测温研究  

Temperature Correlation of Backscattered Ultrasound Time-shifts and Noninvasive Temperature Measurement in Tissue

作　　者：任新颖[1] 吴水才[1] 曾毅[1] 白燕萍[1] 

机构地区：[1]北京工业大学生命科学与生物工程学院,北京100022

出　　处：《中国生物医学工程学报》2006年第3期328-332,共5页Chinese Journal of Biomedical Engineering

基　　金：国家自然科学基金资助项目(30470450);北京市教委基金资助项目(KP0608200201);北京市优秀人才基金资助项目(KW5800200351)。

摘　　要：研究生物组织超声回波时移的温度相关性,以期利用这种相关性实现癌热疗中组织温度的无创检测.以去气水和新鲜离体猪肝为实验研究对象,采集其在一定温度范围（20℃～50℃）内的组织背向反射超声回波信号,通过信号分析探寻超声回波时移与温度的相关性,并利用这种相关性进行无创测温.实验结果表明：①组织内超声声速随温度的变化而变化,它与加热区域内的组织热膨胀共同引起了回波时移的变化;②回波时移的变化与温度变化之间有明显的相关性,且具有较为稳定的线性相关函数;③利用组织超声回波时移的温度相关性进行无创测温是可行的.To study a kind of ultrasound method for measuring tissue temperature in hyperthermia, it is a noninvasive temperature estimation based on time-shifts of baekscattered ultrasound. The experiments were carried out on in fresh pig livers during the temperature range from 20℃ - 50℃, and a series of time-shifts of backscattered ultrasound were obtained. Signal sampling and processing were used to explore the temperature correlation of backscattered ultrasound time-shifts, and tissue temperature was estimated, it has been found that the time-shifts of backscattered ultrasound varied in accordance with the temperature changes in heated tissue, and the trend was linea. Preliminary experimental results showed the feasibility of this ultrasonic noninvasive thermometry.

关 键 词：超声 温度 测量 

分 类 号：R318.08[医药卫生—生物医学工程]