基于CFD的离心式人工心脏泵的溶血预测方法  

Computational Fluid Dynamics Prediction of Shear Stress-related Hemolysis in Centrifugal Blood Pumps

作　　者：王芳群[1] 封志刚[1] 曾培[1] 茹伟民[1] 袁海宇[1] 钱坤喜[1] 

机构地区：[1]江苏大学生物医学工程研究所,镇江212013

出　　处：《中国生物医学工程学报》2006年第3期338-341,345,共5页Chinese Journal of Biomedical Engineering

摘　　要：溶血的定量评价对于人工心脏泵的设计和研究十分重要。本研究应用CFD(computational fluid dynamics)技术,针对两种叶轮设计的离心血泵进行了数值模拟,计算得到了其内部的流线分布。根据溶血、切应力和暴露时间三者之间的幂函数模型,对血泵的溶血进行了预测。最后,用溶血实验结果进行了验证。结果表明,在相同的边界条件下,流线型叶轮泵内的溶血值要小于直叶片叶轮泵,与溶血实验结果一致。可见,应用CFD实现溶血的定量计算是可行的,溶血、切应力和暴露时间之间的幂函数模型能较好地反映血泵的溶血性能。This work investigated a quantitative evaluation of shear stress-related hemolysis in centrifugal blood pumps with different impeller designs. Computational fluid dynamies （CFD） was applied to track the shear stress history of the particle streamlines, The power law model of the relations among the hemolysis, shear stress and exposure time was used to evaluate the hemolysis in the pumps. Hemolysis tests were also conducted to verify the index of hemolysis estimation. Both the estimations and experimentally measured hemolysis levels showed that the hemolysis in a streamlined impeller pump developed by the authors was lower than in the pump with straight vanes in the same boundary conditions. It was proved that CFD is a feasible, useful tool to evaluate the hemolysis levels in blood pumps.

关 键 词：溶血 切应力 CFD 

分 类 号：R318[医药卫生—生物医学工程]