大黄对实验性大鼠坏死性胰腺炎肠道屏障保护作用  

The Protection of Dahuang Juice for Intestinal Mechan-barner and Immuno-barrier in Experimental Acute Necrotizing Pacreatitis

作　　者：邓兆斌[1] 赖少彤[1] 刘艳[2] 蒋俊明[3] 

机构地区：[1]大连大学附属新华医院消化内科,辽宁大连116021 [2]佳木斯中心医院消化内科,黑龙江佳木斯154002 [3]四川大学华西医学中心,四川成都610041

出　　处：《中医药学刊》2006年第6期1011-1012,共2页Study Journal of Traditional Chinese Medicine

基　　金：国家中医药管理局重点课题(92B093)

摘　　要：目的:观察大黄对急性坏死性胰腺炎(ANP)肠道机械屏障和免疫屏障的改变的影响,以生长抑素组做对照。方法:用经胰胆管逆行注入牛磺胆酸钠复制W istar大鼠ANP模型,观察ANP时,两种药物治疗后肠黏膜和胰腺组织结构变化,测定肠内容物中分泌型免疫球蛋白(SIgA),肠组织丙二醛(MDA),血浆淀粉酶(AMY)。结果:ANP时肠黏膜和胰腺发生病理损伤,肠内容物SIgA含量显著下降(P<0.01),肠组织中MDA,血中AMY含量显著升高(均为P<0.01),且MDA与SIgA呈显著负相关(r=-0.8818,r=-0.9236,P<0.01)。大黄可降低肠组织MDA(P<0.01),提高肠内容物S igA含量(P<0.01)。结论:大黄和生长抑素可减轻肠黏膜和胰腺组织损伤,提高肠内容物中SIgA含量。Objective ： To observe the changes of intestinal mechan - harner and immuno - harrier in acute necrotizing pacreatitis and the effects of Dshuang jiuce on the changes compared with the group treated by somatostantin. Methods ： the model of ANP reproduced by infusion of NaTc into biUopancreatitis duct. All animals were sacrificed on 24 hour after reproduced model, SIgA level in intestinal content, MDA level in intestinal mousca, morphology of pancreas and intestinal mousca were observed. Results ： The result showed that intestinal mousca and pancreas dam-age, a decrease of SIgA in intestinal content （ P 〈0.01）, an increase of MDA in mousca （ P 〈 0.01 ） , were occurred in ANP rats. Treatment with dahuang juice markely improved intestinal mousca and pancreatic injury, elevated SIgA level in Cut content（ P 〈 0. 01, P 〈0.01 ）, reduced the levels of MDA in mousca （ P 〈 0. 01, P 〈 0.01 ）. Concluaion ： Dshuang juice and somatostantin attenuated intestinal mech - and immuno - harricer damage and pancreatic tissue injury of experimental ANP, and that elevated the level of SIgA in gut content .

关 键 词：急性胰腺炎 肠道屏障 MDA SIGA 防治 

分 类 号：R285.5[医药卫生—中药学]