干预醛固酮逃逸对心血管疾病的意义  

The Significance about Intervention of Aldosterone′s Escape in Cardiovascular Diseases

作　　者：张丽明[1] 刘新玲[1] 石如海[1] 

机构地区：[1]中国人民解放军第535医院内1科,湖南怀化418008

出　　处：《医学综述》2006年第12期737-739,共3页Medical Recapitulate

摘　　要：醛固酮逃逸现象是指在血管紧张素Ⅱ转化酶抑制剂(angiotensinconvertingenzymeinhibitor,ACEI)应用过程中,血浆醛固酮水平在短期内下降,长期治疗后仍可增高的现象。慢性心力衰竭醛固酮合成和释放增加。钠潴留、电解质紊乱,脂质胶原沉积和纤维化,导致慢性心力衰竭进行性加重。螺内酯的化学结构类似醛固酮,能阻断醛固酮作用。显著降低心力衰竭的总病死率和(或)住院时间,拮抗心律失常,新的选择性醛固酮拮抗剂可作为心力衰竭、高血压病和心肌梗死后强适应症推荐药物。The phenomenon of aldosterone escape means that its serum level will decrease in short time and then increase in long time during the application of ACEI. Its synthesis and releasing is also increased in chronic heart failure. Sodium retention, electrolyte disturbances, lipid collage deposition and fibrosis will result in progressive aggravation of chronic heart failure. Chemical constitution of aldoctone is similar to that of aldosterone which can inhibit its effect,decrease the total aase fatality and/or length of stay of the heart failure and inhibit arrhythmia. The new selective adosterone antagonists can be a high recommended indication medicine in heart failure,hypertension and post-infarction of myocardium.

关 键 词：干预 醛固酮逃逸 心血管疾病 

分 类 号：R541.4[医药卫生—心血管疾病]