类脂囊泡作为头孢噻肟钠药物载体的研究  

Study on niosomes as cefotaxime sodium drug carrier

作　　者：杜美菊[1] 凌翠霞[1] 李娜[2] 赵凤林[2] 李克安[2] 

机构地区：[1]商丘师范学院,河南商丘476000 [2]北京大学化学与分子工程学院,北京10087

出　　处：《化学研究与应用》2006年第6期634-637,共4页Chemical Research and Application

摘　　要：用司盘(Span)系列非离子表面活性剂和胆固醇(CHOL)通过真空旋转一超声波法制备了头孢噻肟钠囊泡,研究了包封条件对包封率的影响及包封后的药物在体外的模拟释放,考察了头孢噻肟钠囊泡的形态和构造。实验表明:Span20与CHOL摩尔比为2∶1,50°C超声30m in,对1.00g/L的注射用头孢噻肟钠的包封率可达55%以上,而且在模拟肠流体和模拟胃流体中均有缓释作用。Cefotaxime sodium was encapsulated in niosomes formed by non- ionic surfactant Span with Choles via a evaperationsonication method. To obtain a higher encapsulation efficiency,factors including the structure of the surfactant, sonicaton, content of the drug and Cholesterol were investigated and optimized. Furthermore, the release behavior of Cefotaxime Sodium encapsulated in the noisome in simulated gastric and intestinal fluid was studied. The morphology and size of the niosomes were visualized by transmission electron microscopy. The results show that the entrapment efficiency of the niosomes for cefotaxime sodium could be as high as 55% under the following experimental conditions：drug concentration 1.00g/L,molar ratio of Span20 to Cholestero 2：1 and sonication for 30min at 50℃. The release profiles in simulated gastric and intestinal fluid showed a controlled release tendency to some extent.

关 键 词：类脂囊泡 药物释放 头孢噻肟钠 

分 类 号：O626.1[理学—有机化学]