G_β类似蛋白─WDR26对细胞增殖的影响  

G-β-like Protein,WDR26 is Involved in Cell Proliferation

作　　者：朱传炳[1] 曾伟奇[1] 朱莹[1] 李大力[1] 袁婺洲[1] 王跃群[1] 李永青[1] 梁宋平[1] 吴秀山[1] 

机构地区：[1]湖南师范大学生命科学学院蛋白质化学与发育生物学教育部重点实验室,中国湖南长沙410081

出　　处：《生命科学研究》2006年第2期123-127,共5页Life Science Research

基　　金：国家自然科学基金资助项目(3021010392;30270722;30270644;30470867;30570265);国家重点基础研究发展计划(973计划)(2005CB522505);教育部长江学者创新团队基金资助项目(IRT0445);湖南省自然科学基金资助项目(04FJ2006;03JJY6009)

摘　　要：WD40重复序列蛋白是一类结构保守、功能复杂的蛋白.关于此类蛋白和细胞内信号传导途径的研究显示,该家族成员很可能通过调控胞内信号转导而影响细胞基本生命活动.在此前的研究中,我们报道了一个新基因WD40repeatprotein26的克隆.其初步研究结果显示WDR26蛋白与MAPK信号途径的负调控相关.在最近的研究中,我们构建了稳定转染pCMV-WDR26表达载体的HeLa细胞系,结果显示WDR26蛋白在HeLa细胞系中的过度表达,能够促进细胞分裂,加快细胞的倍增速度.因此,WDR26很可能具有通过MAPK信号途径调节细胞增殖的功能.WD40 repeat proteins belong to a protein family of conserved structure and complex cellular functions. Previous studies show that some family members have effect on primary cellular process by regulating certain signaling pathway. In earlier study, we reported the cloning of a new gene, which encodes for WD40 repeat protein 26 and showed that it is involved in the negative regulation of MAPK signaling pathway. In this study, we constructed a stable transfected HeLa cell line with pCMV-WDR26, and found that the over-expression of WDR26 promoted cell division and accelerated the proliferation speed. These results suggest that WDR26 can probably regulate cell proliferation through MAPK signaling pathway.

关 键 词：WDR26蛋白 MAPK信号途径 细胞增殖 

分 类 号：Q753[生物学—分子生物学]