低能离子注入对脱氧胸苷的辐照损伤  

Irradiation-induced damage of thymidine by low energy ion implantation

作　　者：邵春林[1] 孙洪奎[1] 余增亮[1] 

机构地区：[1]中国科学院等离子体物理研究所

出　　处：《核技术》1996年第8期484-487,共4页Nuclear Techniques

基　　金：国家自然科学基金

摘　　要：用紫外分光光度法测量了脱氧胸苷（ｄＴＲ）在２０ｋｅＶＮ＋离子束辐照下残余活性Ｓ和碱基Ｔ释放量的剂量效应．发现Ｓ与样品的质量有关，且受损ｄＴＲ分子中约有５０％可产生碱基Ｔ。而强碱、强酸的后处理使这一比例显著下降，平均分别只有２３％和４１％，与γ辐射时的情况相反。With UV spectrophotometry, the dose effectS of residual activity S of thymidine irradiated by 20keV N+ ion beam and of based T released from the irradiated thymidine were studied. It was found that S was related to the irradiated sample's weight, and that about 50% of the damaged dTR molecules was able to produce based T. The post-treatment of strong alkali or strong acid made this proportion be reduced to 23% and 41% respectively, which showed a tendency contrary to that tinder gamma-ray irradiation.

关 键 词：离子束 脱氧胸苷 辐照损伤 

分 类 号：Q691.7[生物学—生物物理学]