肺一氧化碳弥散量测定在系统性红斑狼疮肺间质病变的意义  

SIGNIFICANCE OF THE DIFFUSING CAPACITY OF CARBON MONOXIDE IN PATIENTS OF SYSTEMIC LUPUS ERYTHEMATOSUS COMPLICATED WITH INTERSTITIAL LUNG DISEASE

作　　者：赖映君 邱晨 洪水平[2] 谭艳红[2] 王莹[3] 

机构地区：[1]暨南大学第二临床医学院深圳市人民医院呼吸内科,深圳518020 [2]暨南大学第二临床医学院风湿科 [3]暨南大学第二临床医学院放射科

出　　处：《现代预防医学》2006年第6期898-899,共2页Modern Preventive Medicine

摘　　要：目的:探讨应用一氧化碳弥散量(DLCO)测定对系统性红斑狼疮(SLE)肺间质性病变(ILD)的意义。方法:对80例系统性红斑狼疮进行一氧化碳弥散量检测,并与X线胸片、肺部高分辨CT(HRCT)结果相比较;同时测定70例正常人的DLCO和X线胸片作为对照。结果:DLCO(以一氧化碳弥散吸收率<80%为标准)、肺部HRCT和X线胸片提示ILD的比率分别为45%、34%和18%。而正常人的X线胸片均正常,一氧化碳弥散吸收率≥80%。结论:DLCO和HRCT是检测SLE患者ILD的敏感方法,尤其是DLCO敏感性高、不受X线辐射、对ILD损害程度可进行量化、操作简单、易被患者接受等优点。因此DLCO测定可作为早期监测SLE患者ILD的指标。Objective： To investigate significance of the diffusing capacity of carbon monoxide in patients of systemic lupus erythematosus complicated with interstitial lung disease. Methods： Carbon monoxide diffusing capacity, chest radiography and HRCT of eighty patients of systemic lupus erythematosus （SLE） were studied. Seventy healthy individuals were considered as the control group.Results： 14 of the 80 （18%） patients of SLE were found to be complicated with ILD by chest radiography. HRCT abnormalities for ILD were noted in 27/80 （34%） of the patients of SLE. Alternation of DLCO was present in 36 （45%） patients of SLE. The average value of DLCO were （80 ± 22） % in SLE patients, which were significantry different from that in the healthy controls [DLCO= （105 ±9） % ] （P〈0.01） .Conclusion： As for the diagnosis of ILD in SLE patients, chest radiography was less sensitive than HRCT and DLCO . DLCO , which is highly sensitive without radioactivity, thus, could be the early indictor rnoniting of ILD in patients of SLE.

关 键 词：系统性红斑狼疮 肺间质性病变 一氧化碳弥散量 

分 类 号：R593.241[医药卫生—内科学]