快速心肌显像剂^（99m）Tc—TEBO的标记和动物体内分布实验  

Latelline or rapid myocardial imaging agent TEBO and its animal studies

作　　者：汪芳[1] 杨一峰[1] 钱忠豪[1] 蒋长英[1] 朱蓓玲[1] 顾宇参[1] 许峥[1] 董纪昌[1] 宋纯义[1] 詹福根 

机构地区：[1]上海医科大学附属中山医院,上海医科大学附属肿瘤医院,上海医科大学药学院

出　　处：《核技术》1996年第5期265-268,共4页Nuclear Techniques

摘　　要：报道了用９９ｍＴｃ标记Ｔｅｂｏｒｏｘｉｍｅ（简称ＴＥＢＯ），并在标记后对其质量进行了鉴定。结果表明，其物理性质、化学性质及生物学性质均符合国家制定的放射性药物的质量标准；动物实验表明，小鼠注射量为成人用量的１００倍、观察１５天后，实验组和对照组无差别；注入量为０．１ｍｌ（２０７．ＺｋＢｑ／只），２ｍｉｎ后心肌摄取达峰值１７．７５±０．３３％（ｇｏｒｇａｎ）－１；心肌清除也快，１５ｍｉｎ已清除至８．４２±４．７２％（ｇｏｒｇａｎ）－１。肝脏高峰值在１０ｍｉｎ左右，兔体内的药物动力学特征为快速短时间内完成多体位心肌显像提供药代学基础。new technetium labelled myocardial imaging agent teboroxime is reported. Its quality is identified after labelling.The results indicate that its physical, chemical and biological aspects are in accordance with radiopharmaceutical quality control standard made by our country.The animal experiment shows that there is no difference between the experimental group and the control group after injecting one hundredfold human's dose in mice.After injection 0.1ml(207.2kBq/per mouse),the myocardial peak uptake is observed at the second minute,which is 17.75±0.33%(gorgan)-1, the heart clearance is also rapid,at the 15th minute postinjection,the uptake by myocardium is 8.24±4.72%(g organ)-1.The liver is the major excretion organ.The characteristic of pharmacokinetium in rabbits can be a pharmacokinetics basis for a rapid planar myocardial imaging protol of multiple position.

关 键 词：快速 心肌显像 核素标记 

分 类 号：R816.2[医药卫生—放射医学] R981[医药卫生—临床医学]