影响^（99m）TC－抗CEA单克隆抗体肠癌放免显像的因素研究  

A study of influencing factors upon the radioimnnmoimaging with￣(99m)Tc labelled anti-CEA monoclonal antibody(C_(50))in colorectal carcinoma

作　　者：卢献平[1] 吕斌[1] 蒋宁一[1] 颜登国[1] 陈声乐[1] 邵季书[1] 刘幸光[1] 

机构地区：[1]中山医科大学孙逸仙纪念医院

出　　处：《核技术》1996年第5期281-284,共4页Nuclear Techniques

摘　　要：对２０例病理诊断为原发性肠癌（包括直肠癌和结肠癌）和４例肠癌术后复发病人的放免显像结果与血清ＣＥＡ含量、术中肿瘤大小测定、免疫组织化学染色肿瘤ＣＥＡ染色细胞阳性率以及ＣＥＡ染色阳性在组织中的分布进行了对比研究．结果显示：放免显像质量与血清ＣＥＡ浓度无关（Ｐ＞０．０５）．与肿瘤大小、肿瘤细胞ＣＥＡ反应阳性百分比以及ＣＥＡ阳性反应在组织中的分布有关（Ｐ＜０．０５）。A comparative study has been made among the result of radioinununoimaging with the blood CEA level,the size of the tumor,the CEA content and the distribution in the tumor,the CEA content and the distribution in the resected tumor tissue by immunohistochemical examination in 20 cases of primary colorectal cancer and 4 recurrent cases, were proved by pathologic section. It was shown that the quality of the radiommunoimaging had no relationship with the blood CEA level(P>0.05),but was significantly correlated with the main diameter of tumor, the CEA content and the positive CEA reaction distribution in the tumor tissue (P<0.05).

关 键 词：单克隆抗体 肠肿瘤 放射免疫显像 化学染色 

分 类 号：R817.4[医药卫生—影像医学与核医学] R735.3[医药卫生—放射医学]