麻黄汤配方颗粒剂与标准汤剂的HPLC指纹图谱研究  

HPLC fingerprints of Mahuangtang dispensing granule and standard decoction

作　　者：王丽莉[1] 刘晓秋[1] 陈发奎[1] 

机构地区：[1]沈阳药科大学,辽宁沈阳110016

出　　处：《中成药》2006年第6期784-787,共4页Chinese Traditional Patent Medicine

摘　　要：目的:建立麻黄汤(麻黄、甘草、桂枝和苦杏仁)配方颗粒剂的HPLC指纹图谱,通过与传统汤剂进行比较,为麻黄汤配方颗粒剂的可行性提供依据。方法:采用反相高效液相色谱法,流动相为甲醇-0.01 mol/L磷酸二氢钾水溶液(磷酸调pH=3)进行梯度洗脱。结果:确定了26个共有峰,得到了以甘草次酸为参照的相对峰面积值。结论:两者主要指标成分的相对含量差别不大,麻黄汤配方颗粒剂有其合理性。AIM： To study the difference in main chemical composition and content between Mahuangtang Herb Ephedrae; Radix et Rhizoma Gly Cyrrhizae; Ramulus Cinnamoni; Semen Armeniacea Amarum; dispensing granule and its standard decoction. METHODS： RP-HPLC was used to create fingerprinits with MeOH-0. 01 mol/L KH2PO4（H3PO4 adjusted pH = 3）, a gradient eluting agent. RESULTS： 26 co-possessing peaks were indicated, the retention time and relative peak area were obtained. CONCLUSION： The difference between Mahuangtang dispensing granule and standard decoction is not obvious, the former is rational.

关 键 词：HPLC 指纹图谱 麻黄汤配方颗粒剂 麻黄汤标准汤剂 

分 类 号：R284.1[医药卫生—中药学]