蟾酥固体脂质纳米粒冻干针剂体内药代动力学研究  

Pharmacokinetics of lyophilization of toad venom-loaded solid lipid nanoparticles

作　　者：杨勇[1] 奉建芳[1] 芦洁[1] 罗杰英[2] 

机构地区：[1]上海医药工业研究院药物制剂部 [2]湖南中医学院药学院,湖南长沙410007

出　　处：《中成药》2006年第6期787-790,共4页Chinese Traditional Patent Medicine

基　　金：国家"863"计划项目(2004AA218021);上海市纳米科技与产业发展促进中心项目(0352nml22)

摘　　要：目的:进行了蟾酥固体脂质纳米粒冻干针剂大鼠体内的药代动力学研究。方法:采用RP-HPLC测定了大鼠体内不同时间的华蟾酥毒基、脂蟾毒配基浓度。结果:统计结果显示蟾酥固体脂质纳米粒冻干针剂与蟾酥水溶液的Cm ax、AUCextra、MRT均有显著性差异。结论:蟾酥固体脂质纳米粒冻干针剂能显著地延长蟾酥中华蟾酥毒基、脂蟾毒配基的体内滞留时间,固体脂质纳米粒有望成为改善水难溶性药物体内释放的新型制剂。AIM ： To investigate the pbarmaeokinetics of lyophilization of toad venom （ Venenum Bufouis） -loaded solid lipid nanoparticles （Vs-SLN）. METHODS： Cinobufagin and resibufogenin plasma concentration in rat was determined by RP-HPLC. RESULTS： Statistic test showed that there was significant difference between lyophilization of Vs-SLN and Vs-injection for Cmax, AUCextra , MRT. CONCLUSION ： As the circulating time of the drug in blood was markedly prolonged, Vs-SLN can be developed to a novel preparation for controlled release of lipophil- ic drugs.

关 键 词：蟾酥 固体脂质纳米粒冻干针剂 药代动力学 大鼠 

分 类 号：R285.5[医药卫生—中药学]