慢性肝病血清肝纤维化指标检测的临床意义  

The clinical significance of the four serum indexes of liver fibrosis in patients with chronic hepatitis

作　　者：林少锐[1] 陈瑞烈[1] 郑晓丹[1] 康惠忠[1] 

机构地区：[1]广东省汕头市中心医院感染科,广东汕头515031

出　　处：《世界感染杂志》2006年第3期225-226,共2页World Journal of Infection

摘　　要：目的探讨慢性肝病病人血清透明质酸（HA）、Ⅲ型前胶原（PCⅢ）、IV型胶原（IV-C）、层粘连蛋白（LN）水平及其临床意义。方法应用放射免疫法检测211例慢性肝病病人血清HA、PCⅢ、IV-C及LN水平。结果慢性肝病病情轻重以及不同病程之间HA、PCⅢ、IV-C、LN水平升高有显著差异（P〈0．01），血清HA、PCⅢ、IV-C、LN水平随病情的加重以及病程的延长而逐渐升高。结论慢性肝病病人血清HA、PCⅢ、IV-C、LN水平能反映肝纤维化的程度和肝功能损害程度，对临床诊断及预后判断有重要意义。Objective To detect the sera levels of HA, PCⅢ, IV-C, LN in patients with chronic hepatitis and to explore their clinical significance. Methods The sera levels of HA, PCⅢ, IV-C and LN were detected by radioimmunoassay （RIA） from 211 patients with chronic hepatitis. Results It was found the levels of HA, PCⅢ, IV-C and LN in sera were significantly different between the states and the courses of disease （P〈0.01）. Their levels increased with aggravation of illness and the prolonged course of disease. Conclusion The changes of the sera levels of HA, PCⅢ, IV-C and LN can reflect the degree of liver fibrosis and liver function damage, It is significant for clinical diagnosis and prognosis prediction.

关 键 词：肝纤维化 透明质酸 Ⅲ型前胶原 IV型胶原 层粘连蛋白 

分 类 号：R657.31[医药卫生—外科学]