α_(1)-MG RIA在肾脏疾病诊断中的应用  

THE APPLICATION OF α_(1)-MG RADIOIMMUNOASSAY IN THE DIAGNOSIS OF KIDNEY DISEASES

作　　者：刘桂芬[1] 王建春[1] 张庆峰[1] 刘淑英[1] 韩文生[1] 李志红[2] 

机构地区：[1]沧州市中心医院同位素室 [2]沧州卫生学校

出　　处：《同位素》1996年第2期106-109,共4页Journal of Isotopes

摘　　要：应用α１－ＭＧ放射免疫分析法（α１－ＭＧＲＩＡ），对２７６例正常人（对照组）的血清和尿进行了检测。结果表明：血清正常值为５４．２２±２２．０２ｍｇ／ｌ，尿正常值为５．５７±２．６３ｍｇ／ｌ。同时对３５８例不同疾病患者也进行了检测，其中妊高症、肾功能不全、肾炎等疾病组尿α１－ＭＧ含量与对照组比较有显著性差异（Ｐ＜０．００１），为临床肾脏疾病诊断及肾功能检测提供了可靠、灵敏的指标。该法可在临床上推广应用。A new method for the diagnoses of kidney diseases with α 1 microglobulin(α 1 MG) radioimmunoassay is developed. 276 healthy personsserum and urine are determined by α 1 MG radioimmunoassay. The result shows that the serum normal number is 54.22±22.02 mg/l and the urine 5.57±2.63 mg/l. In contrast, the counterparts of 358 patients with different diseases are also examined. The result shows that there is a remarkable difference between urine α 1 MG content of patients suffering from such diseases as gestation hypertension, renal insufficiency, nephritis and that of the healthy group( P <0.001). The method provides a stable, sensitive index for the diagnoses of kidney diseases and the examination of kidney function.It can be widely used in the clinical diagnosis.

关 键 词：α_(1)-MG 放射免疫测定 肾功能 肾脏疾病 

分 类 号：R446.6[医药卫生—诊断学] R692[医药卫生—临床医学]