人乙肝免疫球蛋白联合重组乙肝疫苗对乙型肝炎父婴传播控制的临床研究  

Chinical Study on Pregnancy of the Paternal Fetal Transmission of Hepatitis B viirus(HBV)by Combination of HBV Vaccine and HBV Immunoglobuoin

作　　者：李穗湘 

机构地区：[1]广东省韶关市第一人民医院,广东韶关512002

出　　处：《中国初级卫生保健》2006年第6期65-66,共2页Chinese Primary Health Care

摘　　要：目的探讨人乙肝免疫球蛋白联合重组乙肝疫苗控制乙型肝炎父婴传播的疗效。方法将符合条件的孕妇共60例分为4组,分别予以单用乙肝免疫球蛋白、乙肝疫苗联合乙肝免疫球蛋白、单用乙肝疫苗及空白对照组。所有孕妇及新生儿出生时均行乙肝三对检测。结果单用乙肝免疫球蛋白组新生儿宫内感染率为13.33%(2/15),重组乙肝疫苗联合乙肝免疫球蛋白组新生儿宫内感染率为6.67%(1/15),单用重组乙肝疫苗组新生儿宫内感染率为13.33%(2/15),不做治疗组新生儿宫内感染率为20.00%(3/15)。结论应用人乙肝免疫球蛋白联合重组乙肝疫苗对阻断HBV父婴传播有效。OBJECTIVES To investigate prospectively therapeutic effect of combination of HBV vaccine and HBV immunoglobulin for controlling the paternal fetal transmission of hepatitis B virus（HBV）. METHODS 60 couples of men with serum HBV-DNA Positive and women without HBV infection were selected and were divided into 4 groups; single use of HBV immunoglobulin group （Ⅰ）, combination of HBV vaccine and HBV immunoglobulin group （ Ⅱ ）, single use of HBV vaccine group （ Ⅲ ） and control group （ Ⅳ ） . All women and the newborns were drawn navel intravenous blood to take the examination of HBV three-pairs. RESULTS The intrauterine- HBV infection rate of the newbors in the Ⅰ gorup was 13.33% （2/15） .The intrauterine-HBV infection rate of the newbors in the Ⅱ group was 6.67%（1/15）. The intrauterine- HBV infection rate of the newbors in the Ⅲ group was 13.33 （2/15）. The intrauterine-HBV infection rate of the newbors in the Ⅳ group 20.00%（3/15）. CONCLUSION The unified immune of HBIG and HBV ac is effective to the blocing of the paternal fetal transmission of hepatitis B virus （HBV） between the mothers and babies.

关 键 词：乙肝疫苗 乙肝免疫球蛋白 乙型肝炎病毒 父婴传播 

分 类 号：R373.21[医药卫生—病原生物学]