6-OHDA损毁大鼠黑质对纹状体感觉门控的影响  

The Effect of Damaging Substantia Nigra with 6-OHDA on Sensory Gating of Striatum in Rats

作　　者：杨黎江[1] 何敏[1] 孔淑贞[1] 马元怡[1] 熊文昌[1] 

机构地区：[1]昆明医学院生理教研室

出　　处：《昆明医学院学报》2006年第3期4-8,共5页Journal of Kunming Medical College

基　　金：云南省教育厅科学研究基金项目(0111441)

摘　　要：目的观察大鼠纹状体是否存在听觉诱发的感觉门控,并观察6-OHDA损毁大鼠黑质对纹状体感觉门控的影响.方法建立6-OHDA致单侧黑质致密带(SNc)DA神经元损毁性PD大鼠模型,于纹状体内埋置记录电极,记录清醒、自由活动状态下正常雌鼠和PD雌鼠纹状体感觉门控(SG)的变化.结果(1)正常雌性SD成年大鼠(C组n=22)纹状体SG的T/C正常值为(60.19±8.83)%;(2)PD组(n=19)SG的T/C值为(42.34±5.81)%,与纹状体SG正常值(C组)相比,其T/C值降低,有显著性差异(P<0.05).结论大鼠纹状体存在听觉感觉门控,损毁大鼠单侧黑质可致同侧纹状体SG的T/C值显著下降.Objective To observe whether sensory gating （SG） exists in striatum and the influence of 6 - hydroxydopamine on sensory gating of striatum in rats. Methods The unilateral substantia nigra compacta （SNc） of rats was damaged by 6 - OHDA and the sensory gating ofthe control and PD rats were recorded with a recording electrode in striatum. Results （ 1 ） The T/C ratio of striatum in normal female rats （ C group, n = 22） was （60. 19 ±8. 83）%. （2） The T/C ratio in Parkinson＇s disease model group （group PD, n =19） was （42. 34 ±5.81 ）%, which decreased compared with C group. There was statistically significant difference be- tween PD group and the C group （ P 〈 0. 05）. Conclusions： Sensory gating exists in Striatum and the unilateral subtantia nigra reduces the T/C ratio of ipsilaeral striatum in female rats.

关 键 词：黑质 纹状体 帕金森氏病 感觉门控 多巴胺 

分 类 号：R338.8[医药卫生—人体生理学]