56例自发酮症初发糖尿病患者的临床分析  

Clinical Analysis of 56 Preliminary Diabetic Patients with Unprovoked Ketosis

作　　者：王霁云[1] 张丽华[1] 尹建梅[1] 王红[1] 

机构地区：[1]天津市第三医院内分泌科,天津300250

出　　处：《中国慢性病预防与控制》2006年第3期185-186,共2页Chinese Journal of Prevention and Control of Chronic Diseases

摘　　要：目的探讨自发酮症或酮症酸中毒起病的初发糖尿病患者的临床特征及分型。方法将56例自发酮症的糖尿病患者根据体质指数分为低体重组、正常体重组和肥胖组,比较各组年龄、性别、发病情况、谷氨脱羧酶抗体阳性率及胰岛功能等方面的差异。结果3组发病时的血糖、酮症或酸中毒程度差别无统计学意义,肥胖组比另外两组甘油三酯及胰岛素水平明显升高,谷氨脱羧酶抗体阳性仅有3例出现在低体重组中。结论自发酮症或酮症酸中毒发病的肥胖糖尿病患者具有不同于非肥胖组的临床特征,其中部分患者应为2型糖尿病,也有患者可考虑为特发性1型糖尿病。Objective To investigate the clinical characteristics and classification of diabetic patients with unprovoked ketoacidosis. Methods According to body mass index （BMI）, 56 patients were. divided into 3 groups： low body weight group （LBW, BMI〈18.5 kg/m^2, n=14 ）, normal body weight group （NBW, BMI 18.6-24.9kg/m^2, n=22）, and over body weight group （OBW, BMI〉25 kg/m^2, n=20）. Clinical characteristics, including age, gender, the course of the disease, positive rate of glutamic acid decarboxylase antibody （GAD-Ab） and the function of islet beta-cell, were compared between these three group. Results There were no significant differences in some clinical features （glyeemia, and ketosis status） at beginning of disease between 3 groups. The level of serum TG and Insulin was higher in OBW group than that in other groups. Only 3 patients were found GAD-Ab positive in LBW group. Conclusion The clinical and immunological characteristics of OBW and LBW patients were quite different, some of the obese patients should be classified into type2 diabetes, and some into idiopathic typel diabetes.

关 键 词：糖尿病 酮症 肥胖 

分 类 号：R587.1[医药卫生—内分泌]