葡多酚对长跑运动员血液流变影响的体内外研究  

The Effect of Grape Procyanidins on Hemorheology in Long Distance Runner in vitro and in vivo

作　　者：王梅蓉[1] 乔向东 钟进义[3] 

机构地区：[1]青岛市人民医院,山东青岛266001 [2]青岛市优秀运动队,山东青岛266003 [3]青岛大学医学院营养与食品卫生系,山东青岛266003

出　　处：《中国慢性病预防与控制》2006年第3期187-189,共3页Chinese Journal of Prevention and Control of Chronic Diseases

基　　金：山东省教育厅2003年重点项目基金资助(03k01)

摘　　要：目的探讨葡多酚(GrapeProcyanidinsGPC)对长跑运动员血液流变学的影响。方法体内实验:22名男性长跑运动员随机分成两组,试验组口服GPC200mgd/,对照组口服淀粉胶囊,连服10d。分别于实验前后清晨采集空腹静脉血,检测血液还原黏度(Er)、红细胞压积(HCT)、血液黏度(Eb)、血浆黏度(Ep)、纤维蛋白原(PFC)、红细胞聚集指数(VAI)。体外实验:采5名男性长跑运动员清晨空腹静脉血加GPC及不同浓度H2O2,检测Er、HCT、Eb、Ep、PFC、VAI。结果体内实验:实验组实验前Er、Eb、Ep分别为6.830±0.164,4.145±0.177,1.647±0.020;实验后分别为6.759±0.158,4.088±0.173,1.621±0.013,P<0.01。其他各项指标变化均有统计学意义(P<0.05);体外实验与体内实验结果相符合。结论GPC在体内和体外条件下均能降低长跑运动员的血液黏度,从而可改善长跑运动员的血液流变状况。Objective To study the effects of Grape Procyanidins （GPC）on hemorheology in long distance runner. Method In vitro study： 22 long distance runners were divided into two groups randomly, the experimental group and control group. With ten days period, the experimental group was given GPC 200 mg per day; while the control group were given the capsule of starch 200 mg per day. In vivo study： the vein blood samples were taken from 5 long distance runners and every example was divided into five parts, and then treated with different concentrations of GPC or H2O2. Items of the hemorheology such as Er, HCT, Eb, Ep, PFC and VAI were tested both in vivo and vitro before and after the study. Results in vitro study： all items of the experimental group showed significant decline at then end of the study than those before the study. The contents of Er, Eb and Ep before the study （6.830±0.164, 4.145± 0.177, 1.647 ±0.020, respectively） were significantly higher than those ＇after the study （6.759 ±0.158, 4.088 ±0.173, 1.621 ±0.013, respectively） （P〈0.01）. The other items also showed significant declined （P〈0.05）. In vivo study： Compered with the control group, the GPC group showed significant decline in items such as Er, Ep, Eb, HCT, PFC and VAI at the end of the study. And the GPC had the function of protecting the cells from oxidation damage by H2O2. Conclusion The GPC could decline the Er, Ep, Eb, HCT, PFC and VAI of long distance runners in vitro and in vivo. GPC had good effect in improving the hemorheology of long distance runner.

关 键 词：葡多酚 血液流变 长跑运动员 

分 类 号：R446.11[医药卫生—诊断学]