海藻真菌次级代谢产物研究进展  

Advances in secondary metabolites of fungi isolated from the marine alga

作　　者：贾铁争[1] 刘红兵[1] 方玉春[1] 朱天骄[1] 顾谦群[1] 朱伟明[1] 

机构地区：[1]海洋药物教育部重点实验室中国海洋大学海洋药物与食品研究所,青岛266003

出　　处：《中国抗生素杂志》2006年第6期328-334,345,共8页Chinese Journal of Antibiotics

基　　金：国家863计划(2003AA624020);国家自然科学基金(No.30472136 & 30470196);山东省和青岛市自然科学基金(No.Z2001C01 & 04-2-JZ-81)。

摘　　要：从宿主为海洋藻类的真菌次级代谢产物中已分离得到许多结构新颖、活性独特的化合物,化学结构类型包括蒽醌、萜类、聚酮、大环内酯、生物碱等,活性涉及抗肿瘤、抗菌、抗藻、抗疟和抗氧化等。本文就近年关于海藻真菌次级代谢产物的研究进展、面临的问题和广阔的应用前景做一综述。Structurally novel and biologically active compounds have been separated from the secondary metabolites of marine alga-derived fungi. The chemical structures of these compounds include anthraquinones, terpenoids, polyketones, macrolides and alkaoids, and the bioactivities include antitumor, antimicrobial, antialgal, antiplasmodial and antioxidant activity. In this paper, we review briefly the research advances and problems on the secondary metabolites of marine agla-derived fungi, and forecast their broad prospect in applications.

关 键 词：海藻真菌 次级代谢产物 生物活性 

分 类 号：Q949.321[生物学—植物学]