T-STAR的结构及生物学功能  

Structure and Biology Function of T-STAR

作　　者：陈兵[1] 郭莲[1] 张玲[1] 何风田[2] 

机构地区：[1]第三军医大学西南医院内分泌科 [2]第三军医大学生物化学教研室,重庆400038

出　　处：《细胞生物学杂志》2006年第3期405-409,共5页Chinese Journal of Cell Biology

基　　金：国家自然科学基金资助项目(No.30271442;No.39980010)~~

摘　　要：T-STAR基因定位于染色体8q24.2,其表达产物为分子量约55kDa的Sam68样蛋白,是STAR(signaltransductionandactivatorofRNA)家族新成员,具有RNA结合蛋白特征性的结合位点和酪氨酸磷酸化功能域。可能通过酪氨酸激酶信号转导系统和pre-mRNA的选择性剪接、加工等途径,参与了精子的发生、细胞的增殖调控、转化细胞的永生化过程并可能与某些疾病有关。The gene of T-STAR is located in chromosome 8q24.2. Its expression product is about 55 kDa Sam68 analog -- a new member of STAR family. T-STAR is an RNA-binding protein that has an RNA-binding domains and function region of tyrosine phosphorylation. T-STAR has been shown to be involved in spermatogenesis, regulation of cell proliferation or immortalization of transform cell by the pathways including tyrosine kinase signal transduction and pre-mRNA alternative splicing or activation of RNA. It is also thought to be related with some diseases.

关 键 词：信号转导 RNA结合蛋白 选择性剪接 精子发生 

分 类 号：Q55[生物学—生物化学]