Rab5a研究进展  

Progress in Rab5a

作　　者：陈香梅[1] 李钰[1] 

机构地区：[1]哈尔滨医科大学医学遗传学研究室,哈尔滨150086

出　　处：《细胞生物学杂志》2006年第3期429-433,共5页Chinese Journal of Cell Biology

基　　金：国家自然科学基金(No.39970396);黑龙江省攻关项目留学回国基金(No.LC04C02);黑龙江省教育厅海外学人科研(合作)项目(No.1054HZ013)资助~~

摘　　要：Rab5a是Rab蛋白家族成员之一,属于小GTP酶。Rab5a是早期胞吞途径中一个重要的限速成分,主要负责调控胞吞中胞吞泡与早期内体的融合。近年来国内外对其研究非常活跃。现对Rab5a的结构、相互作用蛋白及功能的最新研究进展进行综述。Rab5a is one of the members of Rab protein family, which belongs to small GTPases. Rab5a protein is an important rate-limiting component on early endocytic pathways. Recent researches have been strongly supported that Rab5a mainly regulated the fusion of early endosome and controlled the formation of vesicles on the plasma membrane and the downstream delivery of internalized molecules to a number of cellular locations. In this review, the advances on structure, interaction proteins and functions of Rab5a protein are introduced.

关 键 词：RAB5A 小GTP酶 早期内体 胞吞作用 

分 类 号：Q26[生物学—细胞生物学]