吉兰-巴雷综合征患者的流行病学特点及其预后:5年254例资料回顾  

Epidemic characteristics and prognosis of patients with Guillain-Barre syndrome:Review of 254 cases in 5 years

作　　者：代亚美[1] 王德生[1] 王淑荣[1] 胡晓蕾[1] 赵庆杰[1] 张黎明[1] 

机构地区：[1]哈尔滨医科大学第一临床医学院神经内科,黑龙江省哈尔滨市150001

出　　处：《中国临床康复》2006年第24期18-21,共4页Chinese Journal of Clinical Rehabilitation

基　　金：黑龙江省博士后基金资助项目(LRB00097)~~

摘　　要：目的:回顾分析各型吉兰-巴雷综合征患者的临床特征及随访结果,为该病的合理治疗提供依据。方法:①选择2000-01/2005-01在哈尔滨医科大学第一临床医学院收治的吉兰-巴雷综合征患者254例男154例,女100例,平均(35±19)岁;符合Asbury和美国神经病学会制订的急慢性吉兰-巴雷综合征诊断标准的病历资料。②将全部病例的年龄、性别、发病月份、前驱病史、发病至高峰期及住院时间、首发症状、运动症状、感觉症状、波及颅神经、植物神经情况、辅助检查、治疗、随访等均列入Excel病例统计表进行分析统计。并根据吉兰-巴雷综合征电生理记载和临床表现,结合各型诊断标准对资料较为完整者进行分型。比较各型吉兰-巴雷综合征患者年龄、性别分布情况,发病月份分布,前驱病史,临床表现、实验室检查、用药情况和康复特点。③计数资料统计描述采用数字或率形式表示,计量资料以x±s表示,组间计量结果差异比较采用t检验。结果:①分型:经典吉兰-巴雷综合征即急性炎症性多发性神经病89例、吉兰-巴雷综合征变异型急性运动轴索型神经病32例、未分型急性炎症性多发性神经病或急性运动轴索型神经病72例、Fisher综合征14例、慢性吉兰-巴雷综合征34例、复发型吉兰-巴雷综合征5例、全植物神经功能不全3例。②年龄、性别分布:在各型中性别分布大部分为男多于女,仅复发性和植物神经型吉兰-巴雷综合征女>男。慢性吉兰-巴雷综合征及复发型吉兰-巴雷综合征患者年龄明显高于急性炎症性多发性神经病、急性运动轴索型神经病患者(P<0.05～0.01)。③发病月份分布:7,9,10月为吉兰-巴综合征发病高峰。④前驱病史:慢性吉兰-巴雷综合征有病前感染史比例(25%)明显低于急性吉兰-巴雷综合征(53.3%)。⑤临床表现:93%以上患者以四肢无力为主要症状;重者患者都迅速出现肢体�AIM： To review and analyze the clinical features and follow-up results of patients with different types of Guillain-Barre syndrome （GBS）, and provide evidence for the reasonable treatment of GBS. METHODS： ①Totally 254 hospitalized GBS patients aged （35±19） years, including 154 males and 100 females, were selected from the First Clinical Hospital of Harbin Medical University from January 2000 to January 2005. All these patients met the diagnostic criteria of Asbury and Ad Hoc Subcommittee of the American Academy of Neurology for acute and chronic GBS. ②The information of age, sex, months of onset, previous infection history, time of onset, times of onset, peak and hospitalization, first symptom, motor symptom, sensory symptom, cranial nerve involvement, autonomic nerve involvement, accessory examination, treatment and followup, etc were registered and analyzed in the Excel statistical table of cases. The patients with complete data were classified according to electrophysiological records, clinical manifestation and diagnostic criteria of different types of GBS. And those GBS patients were compared in the age, sex, months of onset, previous infection history, clinical manifestations, laboratory examination, medication and rehabilitative characteristics. ③ Enumeration data were described with number or percentage, while measurement data were expressed as Mean ±SD. t test was applied to compare the difference of measurement dada between groups. RESULTS： ①Classification： There were 89 cases of acute inflammatory demyelinating polyneuropathy （AIDP）, 33 cases of acute motor axonal neuropathy （AMAN）, 73 cases of unclassified AIDP or AMAN, 14 cases of Fisher syndrome, 34 cases of chronic inflammatory demyelinating polyneuropathy （CIDP）, 5 cases of recurrent GBS and 3 cases of pan dysautonomia.②Age and sex： There were more males than females suffering from most subtypes of GBS, except recurrent and panautonomia GBS. The CIDP and recurrent GBS patients were older than AMAN and AI

关 键 词：多神经根神经炎 回顾性研究 康复 

分 类 号：R181[医药卫生—流行病学]