TPN联合生长激素对胃肠道恶性肿瘤患者术后应激反应的抑制作用  

Restraining effects of human growth hormone and TPN on stress response after gastrointestinal carcinoma

作　　者：刘敏[1] 马丹[1] 向佳梅[1] 

机构地区：[1]第三军医大学新桥医院肾内科全军肾脏病中心,重庆400037

出　　处：《第三军医大学学报》2006年第13期1430-1431,共2页Journal of Third Military Medical University

摘　　要：目的探讨胃肠道恶性肿瘤术后(total parenteral nutrition,TPN)基础上给予生长激素促进机体合成代谢的机制。方法94例胃肠道恶肿瘤手术患者随机分为TPN组和TPN+GH组,根据间接能量测定仪测定结果,经中心静脉持续输入“全和一”3 L袋营养液,术后1、3、7 d分别测定其TNF-,αIL-1,IL-6,CRP值。结果TPN+GH组的TNF-,αIL-1,IL-6,CRP值在术后第1、3、7 d均低于TPN组。结论外源性生长激素可抑制胃肠道恶性肿瘤患者术后TNF-,αIL-1,IL-6,CRP的产生,进而阻断炎症因子诱导的生长激素不敏感反应所致的合成代谢障碍,促进机体合成代谢。Objective To explore the mechanism of synthesis metabolism intensified by human growth hormone （GH） on the basis of total parenteral nutrition （TPN） for postoperative gastrointestinal carcinoma patients. Methods Totally 94 cases of postoperative gastrointestinal carcinoma patients were randomly divided into TPN group and TPN ＋ GH group. The levels of TNF-α, IL-1, IL-6, CRP were detected on postoperative day 1,3 and 7. Results The levels of TNF-α, IL-1, IL-6, CRP of TPN ＋ GH group were significantly lower than those of TPN group （P 〈 0.01 ）. Conclusion By restraining the inflammatory cytokine production, the synthesis metabolism was promoted by growth hormone in postoperative gastrointestinal carcinoma patients.

关 键 词：生长激素 细胞因子 TPN 

分 类 号：R619[医药卫生—外科学] R735[医药卫生—临床医学]