阿托伐他汀降低不稳定型心绞痛患者血浆尿酸和明胶酶A/B的研究  

Effects of Atovastatin on Reducing Concentration of Serum Uric Acid and Gelatin A/B in Patients with Unstable Angina

作　　者：骆雷鸣[1] 范利[1] 杨雪[1] 刘静[1] 史军[1] 薛浩[1] 朱启伟[1] 叶平[1] 

机构地区：[1]中国人民解放军总医院南楼心血管二科,北京市100853

出　　处：《中国全科医学》2006年第11期895-897,共3页Chinese General Practice

摘　　要：目的比较阿托伐他汀、辛伐他汀对不稳定型心绞痛患者血尿酸、明胶酶A/B(MMP2、MMP9)和心绞痛发作的影响。方法入选110例伴有高尿酸血症的不稳定型心绞痛患者,随机分为阿托伐他汀(AV)组、辛伐他汀(SV)组和对照(NC)组进行治疗,比较治疗1个月后3组患者血尿酸、MMP2、MMP9水平及心绞痛发作的情况。结果治疗后两治疗组患者TC、LDL-C、心绞痛发作频率、持续时间较对照组均有所降低(P<0·05),两治疗组比较,上述指标间差异均无显著性意义(P>0·05);两治疗组患者MMP2、MMP9不同程度下降,SV组降幅更大;AV组患者血尿酸显著降低,SV组无明显变化。结论阿托伐他汀和辛伐他汀都能够降低不稳定型心绞痛患者的总胆固醇和LDL-胆固醇,改善不稳定型心绞痛症状。在治疗合并高尿酸血症的不稳定型心绞痛时,他汀类药物的选择以阿托伐他汀为宜。Objective To compare the effects of atorvastatin and simvastatin on serum uric acid, MMP- 2, MMP-9 and angina onset in patients with unstable angina. Methods A total of 110 unstable angina patients with hyperuricemia was enrolled, they were randomly divided into three groups of AV （atovastatins, 10 mg/d）, SV （simvastatin, 20 mg/d） and control. Serum total cholesterol （TC）, low density lipoprotein cholesterol （LDL- C）, uric acid, MMP- 2, MMP- 9 and onset of angina were observed and analyzed at base line and one month after therapy. Results Compared with control group, the variables including angina frequency, lasting time, concentrations of TC and LDL - C were decreased in AV and SV groups （ P 〈 0. 05 ）, but with no significant difference between the two trial groups （ P 〉 0. 05 ）. The level of serum MMP -2 and MMP -9 in AV and SV groups were reduced, with the latter being obvious ; the level of uric acid in AV group was obviously decreased, but without obvious change in SV group. Conclusion Both statins can reduce the levels of TC and LDL - C, improve the symptoms of patients with unstable angina. The choice of atorvastatin in statins to treat the unstable angina patients complicated with is a favorable.

关 键 词：心绞痛 不稳定型 阿托伐他汀 辛伐他汀 高尿酸血症 明胶酶A 明胶酶B 

分 类 号：R541.42[医药卫生—心血管疾病]